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Hokkaido University Collection of Scholarly and Academic Papers >
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Seco-type beta-Apocarotenoid Generated by beta-Carotene Oxidation Exerts Anti-inflammatory Effects against Activated Macrophages
| Title: | Seco-type beta-Apocarotenoid Generated by beta-Carotene Oxidation Exerts Anti-inflammatory Effects against Activated Macrophages |
| Authors: | Takatani, Naoki Browse this author →KAKEN DB | | Beppu, Fumiaki Browse this author →KAKEN DB | | Yamano, Yumiko Browse this author →KAKEN DB | | Maoka, Takashi Browse this author →KAKEN DB | | Hosokawa, Masashi Browse this author →KAKEN DB |
| Keywords: | seco-beta-apo-8 '-carotenal | | apocarotenoid | | beta-carotene | | anti-inflammation | | macrophage |
| Issue Date: | 25-Feb-2022 |
| Publisher: | 日本油化学会（Japan Oil Chemists' Society） |
| Journal Title: | Journal of oleo science |
| Volume: | 70 |
| Issue: | 4 |
| Start Page: | 549 |
| End Page: | 558 |
| Publisher DOI: | 10.5650/jos.ess20329 |
| Abstract: | beta-Apocarotenoids are the cleavage products of beta-carotene. They are found in plants, carotenoid-containing foods, and animal tissues. However, limited information is available regarding the health benefits of beta-apocarotenoids. Here, we prepared seco-type beta-apocarotenoids through the chemical oxidation of beta-carotene and investigated their anti-inflammatory effects against activated macrophages. Oxidation of beta-carotene with potassium permanganate produced seco-beta-apo-8'-carotenal, in which one end-group formed an "open" beta-ring and the other was cleaved at the C-7',8' position. In lipopolysaccharide-stimulated murine macrophage-like RAW264.7 cells, seco-beta-apo-8'-carotenal inhibited the secretion and mRNA expression of inflammatory mediators such as nitric oxide, interleukin (IL)-6 and IL-1 beta, and monocyte chemoattractant protein-1. Furthermore, seco-beta-apo-8'-carotenal suppressed phosphorylation of c-Jun N-terminal kinase and the inhibitor of nuclear factor (NF)-kappa B as well as the nuclear accumulation of NF-kappa B p65. Notably, since seco-beta-apo-8'-carotenal exhibited remarkable anti-inflammatory activity compared with beta-apo-8'-carotenal, its anti-inflammatory action could depend on the opened beta-ring structure. These results suggest that seco-beta-apo-8'-carotenal has high potential for the prevention of inflammation-related diseases. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/84193 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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