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Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI

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タイトル: Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI
著者: Kusumi, Ichiro 著作を一覧する
Masui, Takuya 著作を一覧する
Kakiuchi, Chihiro 著作を一覧する
Suzuki, Katsuji 著作を一覧する
Akimoto, Tatsuyuki 著作を一覧する
Hashimoto, Ryota 著作を一覧する
Kunugi, Hiroshi 著作を一覧する
Kato, Tadafumi 著作を一覧する
Koyama, Tsukasa 著作を一覧する
キーワード: XBP1
発行日: 2005年12月31日
出版者: Elsevier
誌名: Neuroscience Letters
巻: 391
号: 1-2
開始ページ: 7
終了ページ: 10
出版社 DOI: 10.1016/j.neulet.2005.08.023
抄録: There have been several researches on the role of personality in the pathophysiology of bipolar disorder. Recently, a polymorphism of XBP1, a pivotal gene in the endoplasmic reticulum (ER) stress response, was shown to contribute to the genetic risk factor for bipolar disorder. Therefore, in this study, we examined the relationship between the XBP1 gene polymorphism and the personality traits assessed by two self-rating scales, a shortened version of Temperament and Character Inventory (TCI) and NEO-Five Factor Inventory (NEO-FFI) in healthy subjects. The present results suggested that the XBP1 gene polymorphism was associated with the NEO-FFI score of neuroticism in female subjects. However, no significant differences in the other personality scale scores of both assessments were observed among normal subjects with -116C/C, C/G and G/G genotypes. Further investigations are necessary to examine the relationship in patients with bipolar disorder, or use full version of various self-rating personality assessments.
Relation (URI):
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 久住 一郎


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