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Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI

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Title: Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI
Authors: Kusumi, Ichiro Browse this author →KAKEN DB
Masui, Takuya Browse this author
Kakiuchi, Chihiro Browse this author
Suzuki, Katsuji Browse this author
Akimoto, Tatsuyuki Browse this author
Hashimoto, Ryota Browse this author
Kunugi, Hiroshi Browse this author
Kato, Tadafumi Browse this author
Koyama, Tsukasa Browse this author
Keywords: XBP1
Issue Date: 31-Dec-2005
Publisher: Elsevier
Journal Title: Neuroscience Letters
Volume: 391
Issue: 1-2
Start Page: 7
End Page: 10
Publisher DOI: 10.1016/j.neulet.2005.08.023
PMID: 16154272
Abstract: There have been several researches on the role of personality in the pathophysiology of bipolar disorder. Recently, a polymorphism of XBP1, a pivotal gene in the endoplasmic reticulum (ER) stress response, was shown to contribute to the genetic risk factor for bipolar disorder. Therefore, in this study, we examined the relationship between the XBP1 gene polymorphism and the personality traits assessed by two self-rating scales, a shortened version of Temperament and Character Inventory (TCI) and NEO-Five Factor Inventory (NEO-FFI) in healthy subjects. The present results suggested that the XBP1 gene polymorphism was associated with the NEO-FFI score of neuroticism in female subjects. However, no significant differences in the other personality scale scores of both assessments were observed among normal subjects with -116C/C, C/G and G/G genotypes. Further investigations are necessary to examine the relationship in patients with bipolar disorder, or use full version of various self-rating personality assessments.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 久住 一郎

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