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Morbidity and mortality in antiphospholipid syndrome based on cluster Analysis : a 10-year longitudinal cohort study

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Title: Morbidity and mortality in antiphospholipid syndrome based on cluster Analysis : a 10-year longitudinal cohort study
Authors: Ogata, Yusuke Browse this author
Fujieda, Yuichiro Browse this author →KAKEN DB
Sugawara, Masanari Browse this author
Sato, Taiki Browse this author
Ohnishi, Naoki Browse this author
Kono, Michihito Browse this author →KAKEN DB
Kato, Masaru Browse this author
Oku, Kenji Browse this author →KAKEN DB
Amengual, Olga Browse this author
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: antiphospholipid syndrome (APS)
cardiovascular risks
history of arterial thrombosis
cluster analysis
Issue Date: Mar-2021
Publisher: Oxford University Press
Journal Title: Rheumatology
Volume: 60
Issue: 3
Start Page: 1331
End Page: 1337
Publisher DOI: 10.1093/rheumatology/keaa542
Abstract: Objective. Using cluster analysis, to identify the subgroup of patients with APS with the poorest prognosis and clarify the characteristics of that subgroup. Methods. This is a longitudinal retrospective cohort study of APS patients. Using clinical data and the profile of aPL, cluster analysis was performed to classify the patients into subgroups. Events were defined as thrombosis, severe bleeding, and mortality. Results. A total of 168 patients with APS were included. Cluster analysis classified the patients into three subgroups; Cluster A (n = 61): secondary APS, Cluster B (n = 56): accumulation of cardiovascular risks and arterial thrombosis, Cluster C (n = 61): triple positivity of aPL and venous thrombosis. Cluster B showed significantly higher frequency of the events and higher mortality compared with the other clusters (P = 0.0112 for B vs A and P = 0.0471 for B vs C). Conclusion. Using cluster analysis, we clarified the characteristics of the APS patients with the poorest prognosis. Risk factors for cardiovascular disease may further increase events in patients with APS.
Rights: This is a pre-copyedited, author-produced version of an article accepted for publication in Rheumatology following peer review. The version of record Yusuke Ogata, Yuichiro Fujieda, Masanari Sugawara, Taiki Sato, Naoki Ohnishi, Michihito Kono, Masaru Kato, Kenji Oku, Olga Amengual, Tatsuya Atsumi, Morbidity and mortality in antiphospholipid syndrome based on cluster analysis: a 10-year longitudinal cohort study is available online at:
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藤枝 雄一郎

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