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A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys
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| Title: | A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys |
| Authors: | Sato, Takanori Browse this author | | Takakura, Aya Browse this author | | Lee, Ji-Won Browse this author →KAKEN DB | | Tokunaga, Kazuaki Browse this author | | Matsumori, Haruka Browse this author | | Takao-Kawabata, Ryoko Browse this author | | Iimura, Tadahiro Browse this author →KAKEN DB |
| Keywords: | bone lamellarity | | collagen linearity | | multi-photon microscopy | | SHG (second harmonic generation) | | semi-automatic recognition | | teriparatide |
| Issue Date: | Dec-2021 |
| Publisher: | Oxford University Press |
| Journal Title: | Microscopy |
| Volume: | 70 |
| Issue: | 6 |
| Start Page: | 498 |
| End Page: | 509 |
| Publisher DOI: | 10.1093/jmicro/dfab020 |
| PMID: | 34100544 |
| Abstract: | The lamellar structure of bone, which endows biomechanical rigidity to support the host organism, is observed in mammals, including humans. It is therefore essential to develop a quantitative analysis to evaluate the lamellarity of bone, which would especially be useful for the pharmacological evaluation of anti-osteoporotic drugs. This study applied a current system for the semi-automatic recognition of fluorescence signals to the analysis of un-decalcified bone sections from rat and monkey specimens treated with teriparatide (TPTD). Our analyses on bone formation pattern and collagen topology indicated that TPTD augmented bone lamellarity and bone collagen linearity, which were possibly associated with the recovery of collagen cross-linking, thus endowing bone rigidity. |
| Rights: | © 2021 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/84226 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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