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Hokkaido birth cohort study on environment and children’s health : cohort profile 2021

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Title: Hokkaido birth cohort study on environment and children’s health : cohort profile 2021
Authors: Kishi, Reiko Browse this author →KAKEN DB
Ikeda-Araki, Atsuko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Itoh, Sachiko Browse this author →KAKEN DB
Kobayashi, Sumitaka Browse this author →KAKEN DB
Ait Bamai, Yu Browse this author →KAKEN DB
Yamazaki, Keiko Browse this author →KAKEN DB
Tamura, Naomi Browse this author →KAKEN DB
Minatoya, Machiko Browse this author →KAKEN DB
Ketema, Rahel Mesfin Browse this author
Poudel, Kritika Browse this author
Miura, Ryu Browse this author
Masuda, Hideyuki Browse this author
Itoh, Mariko Browse this author
Yamaguchi, Takeshi Browse this author
Fukunaga, Hisanori Browse this author →KAKEN DB
Ito, Kumiko Browse this author
Goudarzi, Houman Browse this author
Keywords: Early life
Environmental chemicals
Secular trend
Birth size
Allergies andinfectious diseases
Genetic polymorphisms
Issue Date: 22-May-2021
Journal Title: Environmental Health and Preventive Medicine
Volume: 26
Issue: 1
Start Page: 59
Publisher DOI: 10.1186/s12199-021-00980-y
Abstract: Background:The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of twobirth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary objectives areto (1) examine the effects that low-level environmental chemical exposures have on birth outcomes, including birthdefects and growth retardation; (2) follow the development of allergies, infectious diseases, and neurobehavioraldevelopmental disorders, as well as perform a longitudinal observation of child development; (3) identify high-riskgroups based on genetic susceptibility to environmental chemicals; and (4) identify the additive effects of variouschemicals, including tobacco.Methods:The purpose of this report is to provide an update on the progress of the Hokkaido Study, summarizerecent results, and suggest future directions. In particular, this report provides the latest details from questionnairesurveys, face-to-face examinations, and a collection of biological specimens from children and measurements oftheir chemical exposures.Results:The latest findings indicate different risk factors of parental characteristics on birth outcomes and themediating effect between socioeconomic status and children that are small for the gestational age. Maternal serumfolate was not associated with birth defects. Prenatal chemical exposure and smoking were associated with birthsize and growth, as well as cord blood biomarkers, such as adiponectin, leptin, thyroid, and reproductive hormones.We also found significant associations between the chemical levels and neuro development, asthma, and allergies.Conclusions:Chemical exposure to children can occur both before and after birth. Longer follow-up for children iscrucial in birth cohort studies to reinforce the Developmental Origins of Health and Disease hypothesis. In contrast,considering shifts in the exposure levels due to regulation is also essential, which may also change the associationto health outcomes. This study found that individual susceptibility to adverse health effects depends on thegenotype. Epigenome modification of DNA methylation was also discovered, indicating the necessity of examiningmolecular biology perspectives. International collaborations can add a new dimension to the current knowledgeand provide novel discoveries in the future.
Type: article
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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