| Title: | High-Density Lipoprotein Cholesterol and Cardiovascular Events in Patients with Stable Coronary Artery Disease Treated with Statins : An Observation from the REAL-CAD Study |
| Authors: | Omote, Kazunori Browse this author |
| Yokota, Isao Browse this author |
| Nagai, Toshiyuki Browse this author →KAKEN DB |
| Sakuma, Ichiro Browse this author |
| Nakagawa, Yoshihisa Browse this author |
| Kamiya, Kiwamu Browse this author |
| Iwata, Hiroshi Browse this author |
| Miyauchi, Katsumi Browse this author |
| Ozaki, Yukio Browse this author |
| Hibi, Kiyoshi Browse this author |
| Hiro, Takafumi Browse this author |
| Fukumoto, Yoshihiro Browse this author |
| Mori, Hiroyoshi Browse this author |
| Hokimoto, Seiji Browse this author |
| Ohashi, Yasuo Browse this author |
| Ohtsu, Hiroshi Browse this author |
| Ogawa, Hisao Browse this author |
| Daida, Hiroyuki Browse this author |
| Iimuro, Satoshi Browse this author |
| Shimokawa, Hiroaki Browse this author |
| Saito, Yasushi Browse this author |
| Kimura, Takeshi Browse this author |
| Matsuzaki, Masunori Browse this author |
| Nagai, Ryozo Browse this author |
| Anzai, Toshihisa Browse this author →KAKEN DB |
| Keywords: | Lipids |
| Secondary prevention |
| Stable coronary artery disease |
| Statin |
| High-density lipoprotein cholesterol |
| Issue Date: | 1-Jan-2022 |
| Publisher: | Japan Atherosclerosis Society (日本動脈硬化学会) JAS |
| Journal Title: | Journal of atherosclerosis and thrombosis |
| Volume: | 29 |
| Issue: | 1 |
| Start Page: | 50 |
| End Page: | 68 |
| Publisher DOI: | 10.5551/jat.59881 |
| Abstract: | Aim: The association between high-density lipoprotein cholesterol (HDL-C) level after statin therapy and cardiovascular events in patients with stable coronary artery disease (CAD) remains unclear. Thus, in this study, we sought to determine how HDL-C level after statin therapy is associated with cardiovascular events in stable CAD patients. Methods: From the REAL-CAD study which had shown the favorable prognostic effect of high-dose pitavastatin in stable CAD patients with low-density lipoprotein cholesterol (LDL-C) <120 mg/dL, 9,221 patients with HDL-C data at baseline and 6 months, no occurrence of primary outcome at 6 months, and reported non-adherence for pitavastatin, were examined. The primary outcome was a composite of cardiovascular death, non-fatal myocardial infarction, non-fatal ischemic stroke, or unstable angina requiring emergent admission after 6 months of randomization. Absolute difference and ratio of HDL-C levels were defined as (those at 6 months-at baseline) and (absolute difference/baseline) x 100, respectively. Results: During a median follow-up period of 4.0 (IQR 3.2-4.7) years, the primary outcome occurred in 417 (4.5%) patients. The adjusted risk of all HDL-C-related variables (baseline value, 6-month value, absolute, and relative changes) for the primary outcome was not significant (hazard ratio [HR] 0.99, 95% confidence interval [CI] 0.91-1.08, HR 1.03, 95% CI 0.94-1.12, HR 1.05, 95% CI 0.98-1.12, and HR 1.08, 95% CI 0.94-1.24, respectively). Furthermore, adjusted HRs of all HDL-C-related variables remained non-significant for the primary outcome regardless of on-treatment LDL-C level at 6 months. Conclusions: After statin therapy with modestly controlled LDL-C, HDL-C level has little prognostic value in patients with stable CAD. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/84258 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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