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Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury

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Title: Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury
Authors: Endo, Takeshi Browse this author
Kadoya, Ken Browse this author →KAKEN DB
Suzuki, Tomoaki Browse this author
Suzuki, Yuki Browse this author
Terkawi, Mohamad Alaa Browse this author
Kawamura, Daisuke Browse this author
Iwasaki, Norimasa Browse this author →KAKEN DB
Issue Date: 28-Jan-2022
Publisher: Nature Portfolio
Journal Title: npj Regenerative Medicine
Volume: 7
Issue: 1
Start Page: 12
Publisher DOI: 10.1038/s41536-022-00205-y
Abstract: Since Schwann cells (SCs) support axonal growth at development as well as after peripheral nerve injury (PNI), developing SCs might be able to promote axon regeneration after PNI. The purpose of the current study was to elucidate the capability of developing SCs to induce axon regeneration after PNI. SC precursors (SCPs), immature SCs (ISCs), repair SCs (RSCs) from injured nerves, and non-RSCs from intact nerves were tested by grafting into acellular region of rat sciatic nerve with crush injury. Both of developing SCs completely failed to support axon regeneration, whereas both of mature SCs, especially RSCs, induced axon regeneration. Further, RSCs but not SCPs promoted neurite outgrowth of adult dorsal root ganglion neurons. Transcriptome analysis revealed that the gene expression profiles were distinctly different between RSCs and SCPs. These findings indicate that developing SCs are markedly different from mature SCs in terms of functional and molecular aspects and that RSC is a viable candidate for regenerative cell therapy for PNI.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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