HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >

Direct evidence of the preventive effect of milk replacer-based probiotic feeding in calves against severe diarrhea

This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Files in This Item:
Manuscript (Kayasaki et al) ver4.1 (revision).pdf985.51 kBPDFView/Open
Please use this identifier to cite or link to this item:

Title: Direct evidence of the preventive effect of milk replacer-based probiotic feeding in calves against severe diarrhea
Authors: Kayasaki, Fumi Browse this author
Okagawa, Tomohiro Browse this author →KAKEN DB
Konnai, Satoru Browse this author →KAKEN DB
Kohara, Junko Browse this author
Sajiki, Yamato Browse this author
Watari, Kei Browse this author
Ganbaatar, Otgontuya Browse this author
Goto, Shinya Browse this author
Nakamura, Hayato Browse this author
Shimakura, Honami Browse this author
Minato, Erina Browse this author
Kobayashi, Atsushi Browse this author
Kubota, Manabu Browse this author
Terasaki, Nobuhiro Browse this author
Takeda, Akira Browse this author
Noda, Haruka Browse this author
Honma, Mitsuru Browse this author
Maekawa, Naoya Browse this author
Murata, Shiro Browse this author →KAKEN DB
Ohashi, Kazuhiko Browse this author →KAKEN DB
Keywords: Calf diarrhea
Fermented milk replacer
Lactic acid bacteria-supplemented milk replacer
Issue Date: Mar-2021
Publisher: Elsevier
Journal Title: Veterinary microbiology
Volume: 254
Start Page: 108976
Publisher DOI: 10.1016/j.vetmic.2020.108976
Abstract: Diarrhea is a major cause of death in calves and this is linked directly to economic loss in the cattle industry. Fermented milk replacer (FMR) has been used widely in clinical settings for calf feeding to improve its health and growth. However, the protective efficacy of FMR on calf diarrhea remains unclear. In this study, we verified the preventive effects of FMR feeding on calf diarrhea using an experimental infection model of bovine rotavirus (BRV) in newborn calves and a field study in dairy farms with calf diarrhea. In addition, we evaluated the protective efficacy of lactic acid bacteria-supplemented milk replacer (LAB-MR) in an experimental infection model. In the experimental infection, calves fed FMR or high-concentrated LAB-MR had diarrhea, but the water content of feces was lower and more stable than that of calves fed normal milk replacer. The amount of milk intake also decreased temporarily, but recovered immediately in the FMR- and LAB-MR-fed calves. As compared with the control calves, FMR- or LAB-MR-fed calves showed less severe or reduced histopathological lesions of enteritis in the intestinal mucosa. In a field study using dairy calves, FMR feeding significantly reduced the incidence of enteritis, mortality from enteritis, duration of a series of treatment for enteritis, number of consultations, and cost of medical care for the disease. These results suggest that feeding milk replacer-based probiotics to calves reduces the severity of diarrhea and tissue damage to the intestinal tract caused by BRV infection and provides significant clinical benefits to the prevention and treatment of calf diarrhea.
Rights: © <2021>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 今内 覚

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University