HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >

Electrical Storm as an Independent Mortality Risk in Patients with Preserved or Moderately Reduced Left Ventricular Function Results from a Japanese Nationwide Registry

Files in This Item:

The file(s) associated with this item can be obtained from the following URL: https://doi.org/10.1536/ihj.20-832


Title: Electrical Storm as an Independent Mortality Risk in Patients with Preserved or Moderately Reduced Left Ventricular Function Results from a Japanese Nationwide Registry
Authors: Watanabe, Masaya Browse this author →KAKEN DB
Yokoshiki, Hisashi Browse this author →KAKEN DB
Noda, Takashi Browse this author
Yokota, Isao Browse this author →KAKEN DB
Nitta, Takashi Browse this author
Aizawa, Yoshifusa Browse this author
Ohe, Tohru Browse this author
Kurita, Takashi Browse this author
Keywords: Ventricular tachycardia
Non-ischemic heart disease
Mortality
Implantable cardioverter-defibrillator
Issue Date: 29-Nov-2021
Publisher: International Heart Journal Association
Journal Title: International heart journal
Volume: 62
Issue: 6
Start Page: 1249
End Page: 1256
Publisher DOI: 10.1536/ihj.20-832
Abstract: Electrical storm (ES), defined by 3 or more occurrences of ventricular arrhythmias within 24 hours, has been shown to be associated with an increased risk of mortality; however, detailed information remains lacking. We aimed to examine the incidence and determinants of ES and its impact on mortality in patients enrolled in the nationwide implantable cardioverter-defibrillator (ICD) registry. We studied 1,256 patients (age 65 +/- 12 years) who had structural heart disease with an ICD. The patients were classified into reduced ejection fraction (EF < 35%; 657 (52%) patients) and preserved or moderately reduced EF (EF >= 35%; 599 (48%) patients). ES occurred in 49 (7%) and 36 (6%) patients in the EF < 35% and EF >= 35% groups (log-rank P = 0.297) during the median follow-up of 2.3 years. ICD with resynchronization therapy was associated with a lower incidence of ES in patients with EF < 35%. Non-ischemic heart disease and diuretics were associated with ES in patients with EF >= 35%. During the follow-up, 10/49 (20%) patients with ES and 80/608 patients (13%) without ES died in patients with EF < 35%, while 7/36 (19%) patients with ES and 38/563 patients (7%) without ES died in those with EF >= 35%. We have created 4 Cox multivariate models. All models showed approximately 2-fold higher hazard ratios in patients with EF >= 35% compared to EF < 35%. Our study showed that the determinants of ES differed between EF < 35% and EF >= 35%. The impact of ES for mortality was numerically higher in EF >= 35% than in EF < 35%, although a significant interaction was not detected.
Type: article
URI: http://hdl.handle.net/2115/84302
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 

 - Hokkaido University