HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Center for Environmental and Health Sciences >
Peer-reviewed Journal Articles, etc >

Nonylphenol exposure in 7-year-old Japanese children between 2012 and 2017– Estimation of daily intakes based on novel urinary metabolites

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: Nonylphenol exposure in 7-year-old Japanese children between 2012 and 2017– Estimation of daily intakes based on novel urinary metabolites
Authors: Ringbeck, Benedikt Browse this author
Bury, Daniel Browse this author
Ikeda-Araki, Atsuko Browse this author →KAKEN DB
Ait Bamai, Yu Browse this author →KAKEN DB
Ketema, Rahel Mesfin Browse this author
Miyashita, Chihiro Browse this author →KAKEN DB
Brüning, Thomas Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Koch, Holger M. Browse this author
Keywords: Nonylphenol
Issue Date: Mar-2022
Publisher: Elsevier
Journal Title: Environment International
Volume: 161
Start Page: 107145
Publisher DOI: 10.1016/j.envint.2022.107145
Abstract: Nonylphenol (NP) has been under scrutiny for decades due to its endocrine-disrupting properties and its ubiquity in the environment. Despite its widespread occurrence, robust and reliable exposure data are rare. In this study, we used human biomonitoring (HBM) measuring the novel urinary alkyl-chain-oxidized biomarkers OH-NP and oxo-NP to determine NP exposure in 7-year-old Japanese children. The new biomarkers are advantageous over measuring unchanged NP because they are not prone to external contamination. We analyzed 180 first morning void urine samples collected between 2012 and 2017. OH-NP and oxo-NP were detected in 100% and 66% of samples at median concentrations of 2.69 and 0.36 μg/L, respectively. 10-fold concentration differences between OH-NP and oxo-NP are in line with recent findings on human NP metabolism. Based on OH-NP we back- calculated median and maximum NP daily intakes (DI) of 0.14 and 0.95 μg/(kg bw*d). These DIs are rather close to but still below the current provisional tolerable daily intake of 5 μg/(kg bw*d) by the Danish Envi-ronmental Protection Agency. Between 2012 and 2017 the DIs decreased by an average of 4.7% per year. We observed no seasonal changes or gender differences and questionnaire data on food consumption, housing characteristics or pesticide use showed no clear associations with NP exposure. Urinary OH-NP was weakly associated with the oxidative stress (lipid peroxidation) biomarkers N-ε-hexanoyl-lysine (HEL) and trans-4-hy-droxy-2-nonenal (HNE) (Spearman ρ =0.30 and 0.22, respectively), but not with 8-hydroxy-2′-deoxyguanosine (8-OHdG). Further research is needed to identify and understand the major sources of NP exposure and to investigate a potential role in oxidative stress. This study is the first to investigate NP exposure in Japanese children based on robust and sensitive HBM data. It is a first step to fill the long-standing gap in quantitative human NP exposure monitoring and risk assessment.
Rights: © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University