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Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects

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Title: Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects
Authors: Kusumi, Ichiro Browse this author →KAKEN DB
Masui, Takuya Browse this author
Kakiuchi, Chihiro Browse this author
Suzuki, Katsuji Browse this author
Akimoto, Tatsuyuki Browse this author
Hashimoto, Ryota Browse this author
Kunugi, Hiroshi Browse this author
Kato, Tadafumi Browse this author
Kayama, Tsukasa Browse this author
Keywords: Calcium
Endoplamic reticulum
Bipolar disorder
Healthy subject
Issue Date: 7-Oct-2004
Publisher: Elsevier
Journal Title: Neuroscience Letters
Volume: 369
Issue: 1
Start Page: 1
End Page: 3
Publisher DOI: 10.1016/j.neulet.2004.07.003
PMID: 15380296
Abstract: Dysregulations of calcium (Ca) homeostasis may be involved in the pathophysiology of bipolar disorder. Enhanced Ca response to various agonists in peripheral blood cells is one of a few confirmed biological markers for bipolar disorder. Recently, a polymorphism of XBP1, a pivotal gene in the endoplasmic reticulum (ER) stress response, was shown to contribute to the genetic risk factor for bipolar disorder. Thus, in this study, we examined the relationship between the XBP1 gene polymorphism and the Ca signaling in the platelets of healthy controls. The present results suggest no significant difference in the basal Ca level or 5-HT-induced Ca mobilization among normal subjects with -116C/C, C/G and G/G genotypes. Further investigations are necessary to examine the relationship in the different peripheral blood cells and/or in larger samples from patients with bipolar disorder.
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Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 久住 一郎

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