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Acute Oral Calcium Suppresses Food Intake Through Enhanced Peptide-YY Secretion Mediated by the Calcium-Sensing Receptor in Rats

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Title: Acute Oral Calcium Suppresses Food Intake Through Enhanced Peptide-YY Secretion Mediated by the Calcium-Sensing Receptor in Rats
Authors: Igarashi, Akiho Browse this author
Ogasawara, Shono Browse this author
Takagi, Ryo Browse this author
Okada, Kazufumi Browse this author
Ito, Yoichi M. Browse this author →KAKEN DB
Hara, Hiroshi Browse this author →KAKEN DB
Hira, Tohru Browse this author →KAKEN DB
Keywords: calcium-sensing receptor
dietary calcium
Issue Date: 9-Mar-2021
Publisher: Oxford University Press
Journal Title: Journal of nutrition
Volume: 151
Issue: 5
Start Page: 1320
End Page: 1328
Publisher DOI: 10.1093/jn/nxab013
Abstract: Background: Dietary calcium has been proposed to reduce appetite in human studies. Postprandial satiety is mainly controlled by gut hormones. However, the effect of calcium on appetite and the role of gut hormones remain unclear. Objectives: We examined whether oral administration of calcium reduces food intake in rats and investigated the underlying mechanism. Methods: Male Sprague Dawley rats (8-12 wk old) were used after an overnight fastifffng. In a series of 2 trials with 1-wk interval between challenges, food intake was measured 0.5-24 h after oral gavage of a vehicle (saline containing 1.5% carboxymethyl cellulose) as the control treatment, or the vehicle containing various calcium compounds (calcium chloride (CaCl2), calcium carbonate, calcium lactate, in a random order) at 150 mg calcium/kg dose. A conditional taste aversion test was conducted. In separate experiments, plasma calcium and gut hormone concentrations were measured 15 or 30 min after oral administration of the calcium compounds. In anesthetized rats, portal peptide-YY (PYY) concentrations were measured after intraluminal administration of a liquid meal with or without additional calcium. Results: Oral CaCl2 reduced food intake acutely (30 min, similar to 20%, P < 0.05) compared with control rats, without taste aversion. Plasma PYY concentration was higher (100%, P < 0.05) in CaCl2-preloaded rats than in control rats, 15 min after administration. In anesthetized rats, luminal meal + CaCl2 induced a 4-fold higher increase in plasma PYY than the control treatment did. Oral administration of a calcium-sensing receptor (CaSR) agonist suppressed food intake (similar to 30%, P < 0.05), but CaCl2 and CaSR agonist did not suppress food intake under treatment with a PYY receptor antagonist. Furthermore, the CaSR antagonist attenuated the effect of CaCl2 on food intake. Conclusions: CaCl2 suppresses food intake partly by increasing CaSR-mediated PYY secretion in rats. Our findings could at least partially explain the satiating effect of calcium.
Rights: This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Nutrition following peer review. The version of record Akiho Igarashi, Shono Ogasawara, Ryo Takagi, Kazufumi Okada, Yoichi M Ito, Hiroshi Hara, Tohru Hira, Acute Oral Calcium Suppresses Food Intake Through Enhanced Peptide-YY Secretion Mediated by the Calcium-Sensing Receptor in Rats, The Journal of Nutrition, Volume 151, Issue 5, May 2021, Pages 1320-1328. is available online at:
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 比良 徹

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