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Treatment response in depressed patients with enhanced Ca mobilization stimulated by serotonin
| Title: | Treatment response in depressed patients with enhanced Ca mobilization stimulated by serotonin |
| Authors: | Kusumi, Ichiro Browse this author →KAKEN DB | | Suzuki, Katsuji Browse this author | | Sasaki, Yuki Browse this author | | Kameda, Kensuke Browse this author | | Koyama, Tsukasa Browse this author |
| Keywords: | Calcium | | Serotonin | | mood disorder | | treatment response | | Platelet |
| Issue Date: | Dec-2000 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Neuropsychopharmacology |
| Volume: | 23 |
| Issue: | 6 |
| Start Page: | 690 |
| End Page: | 696 |
| Publisher DOI: | 10.1038/sj.npp.1395557 |
| Abstract: | Serotonin (5-HT)-stimulated intraplatelet calcium (Ca) mobilization has been shown to be enhanced in nonmedicated depressive patients by many studies. However, there has not been any longitudinal follow-up study of this parameter. We examined the relationship between treatment response and pretreatment value of the 5-HT-induced Ca response. The 5-HT(10uM)-induced intraplatelet Ca mobilization was measured in 98 nonmedicated depressive patients (24 bipolar disorders, 51 melancholic major depressive disorder and 23 non-melancholic major depressive disorder). These patients were followed up prospectively for a further period of 5 years. The depressed patients with enhanced Ca response to 5-HT in bipolar disorders exhibited a good response to mood stabilizers but those in major depressive disorders showed a poor response to antidepressants. These findings suggest the possibility that the 5-HT-induced intraplatelet Ca response may be a good predictor of treatment response in depressed patients. Longer longitudinal follow-up studies are needed in larger samples to examine that this parameter may be a specific biological marker for unipolar-bipolar dichotomy. |
| Relation: | http://www.nature.com/npp/index.html |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/8436 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 久住 一郎
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