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Treatment response in depressed patients with enhanced Ca mobilization stimulated by serotonin

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タイトル: Treatment response in depressed patients with enhanced Ca mobilization stimulated by serotonin
著者: Kusumi, Ichiro 著作を一覧する
Suzuki, Katsuji 著作を一覧する
Sasaki, Yuki 著作を一覧する
Kameda, Kensuke 著作を一覧する
Koyama, Tsukasa 著作を一覧する
キーワード: Calcium
Serotonin
mood disorder
treatment response
Platelet
発行日: 2000年12月
出版者: Nature Publishing Group
誌名: Neuropsychopharmacology
巻: 23
号: 6
開始ページ: 690
終了ページ: 696
出版社 DOI: 10.1038/sj.npp.1395557
抄録: Serotonin (5-HT)-stimulated intraplatelet calcium (Ca) mobilization has been shown to be enhanced in nonmedicated depressive patients by many studies. However, there has not been any longitudinal follow-up study of this parameter. We examined the relationship between treatment response and pretreatment value of the 5-HT-induced Ca response. The 5-HT(10uM)-induced intraplatelet Ca mobilization was measured in 98 nonmedicated depressive patients (24 bipolar disorders, 51 melancholic major depressive disorder and 23 non-melancholic major depressive disorder). These patients were followed up prospectively for a further period of 5 years. The depressed patients with enhanced Ca response to 5-HT in bipolar disorders exhibited a good response to mood stabilizers but those in major depressive disorders showed a poor response to antidepressants. These findings suggest the possibility that the 5-HT-induced intraplatelet Ca response may be a good predictor of treatment response in depressed patients. Longer longitudinal follow-up studies are needed in larger samples to examine that this parameter may be a specific biological marker for unipolar-bipolar dichotomy.
Relation (URI): http://www.nature.com/npp/index.html
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/8436
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 久住 一郎

 

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