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Treatment response in depressed patients with enhanced Ca mobilization stimulated by serotonin

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Title: Treatment response in depressed patients with enhanced Ca mobilization stimulated by serotonin
Authors: Kusumi, Ichiro Browse this author →KAKEN DB
Suzuki, Katsuji Browse this author
Sasaki, Yuki Browse this author
Kameda, Kensuke Browse this author
Koyama, Tsukasa Browse this author
Keywords: Calcium
mood disorder
treatment response
Issue Date: Dec-2000
Publisher: Nature Publishing Group
Journal Title: Neuropsychopharmacology
Volume: 23
Issue: 6
Start Page: 690
End Page: 696
Publisher DOI: 10.1038/sj.npp.1395557
Abstract: Serotonin (5-HT)-stimulated intraplatelet calcium (Ca) mobilization has been shown to be enhanced in nonmedicated depressive patients by many studies. However, there has not been any longitudinal follow-up study of this parameter. We examined the relationship between treatment response and pretreatment value of the 5-HT-induced Ca response. The 5-HT(10uM)-induced intraplatelet Ca mobilization was measured in 98 nonmedicated depressive patients (24 bipolar disorders, 51 melancholic major depressive disorder and 23 non-melancholic major depressive disorder). These patients were followed up prospectively for a further period of 5 years. The depressed patients with enhanced Ca response to 5-HT in bipolar disorders exhibited a good response to mood stabilizers but those in major depressive disorders showed a poor response to antidepressants. These findings suggest the possibility that the 5-HT-induced intraplatelet Ca response may be a good predictor of treatment response in depressed patients. Longer longitudinal follow-up studies are needed in larger samples to examine that this parameter may be a specific biological marker for unipolar-bipolar dichotomy.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 久住 一郎

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