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Differential Effects of Subchronic Treatments with Atypical Antipsychotic Drugs on Dopamine D2 and Serotonin 5-HT2A Receptors in the Rat Brain
Title: | Differential Effects of Subchronic Treatments with Atypical Antipsychotic Drugs on Dopamine D2 and Serotonin 5-HT2A Receptors in the Rat Brain |
Authors: | Kusumi, Ichiro Browse this author →KAKEN DB | Takahashi, Yoshito Browse this author | Suzuki, Katsuji Browse this author | Kameda, Kensuke Browse this author | Koyama, Tsukasa Browse this author |
Keywords: | Up-regulation | dopamine D2 receptor | a typical antipsychotic drug | serotonin 5-HT2A receptor | in vivo occupation |
Issue Date: | Mar-2000 |
Publisher: | Springer Wien |
Journal Title: | Journal of Neural Transmission |
Volume: | 107 |
Issue: | 3 |
Start Page: | 295 |
End Page: | 302 |
Publisher DOI: | 10.1007/s007020050024 |
PMID: | 10821438 |
Abstract: | The effects of 3-week treatment with a typical antipsychotic drug chlorpromazine and three atypical antipsychotic drugs (risperidone, olanzapine and perospirone) on the binding to dopamine D2 and serotonin 5-HT2A receptors were examined in the rat striatum and frontal cortex, respectively. Subchronic treatment with chlorpromazine (10 mg/kg) and perospirone (1 mg/kg) significantly increased D2 receptors, while no increase was observed with lower dose of chlorpromazine (5 mg/kg), perospirone (0.1 mg/kg), risperidone (0.25, 0.5 mg/kg) or olanzapine (1, 2 mg/kg). On the other hand, 3-week administration of chlorpromazine (5, 10 mg/kg) and olanzapine (1, 2 mg/kg) significantly decreased 5-HT2A receptors, but risperidone (0.25, 0.5 mg/kg) or perospirone (0.1, 1 mg/kg) had no effect. The measurement of in vivo drug occupation for D2 and 5-HT2A receptors using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) suggested that high occupation of 5-HT2A receptors with lower D2 receptor occupancy might be involved in the absence of up-regulation of D2 receptors after subchronic treatment with some atypical antipsychotic drugs. |
Rights: | The original publication is available at http://www.springerlink.com/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/8437 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 久住 一郎
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