HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >

Differential Effects of Subchronic Treatments with Atypical Antipsychotic Drugs on Dopamine D2 and Serotonin 5-HT2A Receptors in the Rat Brain

Files in This Item:
JNT99.pdf156.92 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/8437

Title: Differential Effects of Subchronic Treatments with Atypical Antipsychotic Drugs on Dopamine D2 and Serotonin 5-HT2A Receptors in the Rat Brain
Authors: Kusumi, Ichiro Browse this author →KAKEN DB
Takahashi, Yoshito Browse this author
Suzuki, Katsuji Browse this author
Kameda, Kensuke Browse this author
Koyama, Tsukasa Browse this author
Keywords: Up-regulation
dopamine D2 receptor
a typical antipsychotic drug
serotonin 5-HT2A receptor
in vivo occupation
Issue Date: Mar-2000
Publisher: Springer Wien
Journal Title: Journal of Neural Transmission
Volume: 107
Issue: 3
Start Page: 295
End Page: 302
Publisher DOI: 10.1007/s007020050024
PMID: 10821438
Abstract: The effects of 3-week treatment with a typical antipsychotic drug chlorpromazine and three atypical antipsychotic drugs (risperidone, olanzapine and perospirone) on the binding to dopamine D2 and serotonin 5-HT2A receptors were examined in the rat striatum and frontal cortex, respectively. Subchronic treatment with chlorpromazine (10 mg/kg) and perospirone (1 mg/kg) significantly increased D2 receptors, while no increase was observed with lower dose of chlorpromazine (5 mg/kg), perospirone (0.1 mg/kg), risperidone (0.25, 0.5 mg/kg) or olanzapine (1, 2 mg/kg). On the other hand, 3-week administration of chlorpromazine (5, 10 mg/kg) and olanzapine (1, 2 mg/kg) significantly decreased 5-HT2A receptors, but risperidone (0.25, 0.5 mg/kg) or perospirone (0.1, 1 mg/kg) had no effect. The measurement of in vivo drug occupation for D2 and 5-HT2A receptors using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) suggested that high occupation of 5-HT2A receptors with lower D2 receptor occupancy might be involved in the absence of up-regulation of D2 receptors after subchronic treatment with some atypical antipsychotic drugs.
Rights: The original publication is available at http://www.springerlink.com/
Type: article (author version)
URI: http://hdl.handle.net/2115/8437
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 久住 一郎

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

 - Hokkaido University