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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Interplay between Inflammation and Pathological Bone Resorption : Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives
| Title: | Interplay between Inflammation and Pathological Bone Resorption : Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives |
| Authors: | Terkawi, M. Alaa Browse this author | | Matsumae, Gen Browse this author | | Shimizu, Tomohiro Browse this author →KAKEN DB | | Takahashi, Daisuke Browse this author →KAKEN DB | | Kadoya, Ken Browse this author →KAKEN DB | | Iwasaki, Norimasa Browse this author →KAKEN DB |
| Keywords: | bone | | inflammation | | remodeling | | pathological bone resorption | | bone osteolytic diseases |
| Issue Date: | 4-Feb-2022 |
| Publisher: | MDPI |
| Journal Title: | International Journal of Molecular Sciences |
| Volume: | 23 |
| Issue: | 3 |
| Start Page: | 1786 |
| Publisher DOI: | 10.3390/ijms23031786 |
| Abstract: | Bone is a mineralized and elastic connective tissue that provides fundamental functions in the human body, including mechanical support to the muscles and joints, protection of vital organs and storage of minerals. Bone is a metabolically active organ that undergoes continuous remodeling processes to maintain its architecture, shape, and function throughout life. One of the most important medical discoveries of recent decades has been that the immune system is involved in bone remodeling. Indeed, chronic inflammation has been recognized as the most significant factor influencing bone homeostasis, causing a shift in the bone remodeling process toward pathological bone resorption. Bone osteolytic diseases typified by excessive bone resorption account for one of the greatest causes of disability worldwide, with significant economic and public health burdens. From this perspective, we discuss the recent findings and discoveries highlighting the cellular and molecular mechanisms that regulate this process in the bone microenvironment, in addition to the current therapeutic strategies for the treatment of osteolytic bone diseases. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/84462 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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