| Title: | Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation |
| Authors: | Saito, Akatsuki Browse this author |
| Irie, Takashi Browse this author |
| Suzuki, Rigel Browse this author |
| Maemura, Tadashi Browse this author |
| Nasser, Hesham Browse this author |
| Uriu, Keiya Browse this author |
| Kosugi, Yusuke Browse this author |
| Shirakawa, Kotaro Browse this author |
| Sadamasu, Kenji Browse this author |
| Kimura, Izumi Browse this author |
| Ito, Jumpei Browse this author |
| Wu, Jiaqi Browse this author |
| Iwatsuki-Horimoto, Kiyoko Browse this author |
| Ito, Mutsumi Browse this author |
| Yamayoshi, Seiya Browse this author |
| Loeber, Samantha Browse this author |
| Tsuda, Masumi Browse this author |
| Wang, Lei Browse this author |
| Ozono, Seiya Browse this author |
| Butlertanaka, Erika P. Browse this author |
| Tanaka, Yuri L. Browse this author |
| Shimizu, Ryo Browse this author |
| Shimizu, Kenta Browse this author |
| Yoshimatsu, Kumiko Browse this author |
| Kawabata, Ryoko Browse this author |
| Sakaguchi, Takemasa Browse this author |
| Tokunaga, Kenzo Browse this author |
| Yoshida, Isao Browse this author |
| Asakura, Hiroyuki Browse this author |
| Nagashima, Mami Browse this author |
| Kazuma, Yasuhiro Browse this author |
| Nomura, Ryosuke Browse this author |
| Horisawa, Yoshihito Browse this author |
| Yoshimura, Kazuhisa Browse this author |
| Takaori-Kondo, Akifumi Browse this author |
| Imai, Masaki Browse this author |
| Tanaka, Shinya Browse this author →KAKEN DB |
| Nakagawa, So Browse this author |
| Ikeda, Terumasa Browse this author |
| Fukuhara, Takasuke Browse this author →KAKEN DB |
| Kawaoka, Yoshihiro Browse this author |
| Sato, Kei Browse this author |
| Issue Date: | 10-Feb-2022 |
| Publisher: | Nature Portfolio |
| Journal Title: | Nature |
| Volume: | 602 |
| Issue: | 7896 |
| Start Page: | 300 |
| End Page: | 306 |
| Publisher DOI: | 10.1038/s41586-021-04266-9 |
| Abstract: | During the current coronavirus disease 2019 (COVID-19) pandemic, a variety of mutations have accumulated in the viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and, at the time of writing, four variants of concern are considered to be potentially hazardous to human society(1). The recently emerged B.1.617.2/Delta variant of concern is closely associated with the COVID-19 surge that occurred in India in the spring of 2021 (ref.(2)). However, the virological properties of B.1.617.2/Delta remain unclear. Here we show that the B.1.617.2/Delta variant is highly fusogenic and notably more pathogenic than prototypic SARS-CoV-2 in infected hamsters. The P681R mutation in the spike protein, which is highly conserved in this lineage, facilitates cleavage of the spike protein and enhances viral fusogenicity. Moreover, we demonstrate that the P681R-bearing virus exhibits higher pathogenicity compared with its parental virus. Our data suggest that the P681R mutation is a hallmark of the virological phenotype of the B.1.617.2/Delta variant and is associated with enhanced pathogenicity. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/84468 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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