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GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose

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Title: GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose
Authors: Iwasaki, Yusaku Browse this author
Sendo, Mio Browse this author
Dezaki, Katsuya Browse this author
Hira, Tohru Browse this author →KAKEN DB
Sato, Takehiro Browse this author
Nakata, Masanori Browse this author
Goswami, Chayon Browse this author
Aoki, Ryohei Browse this author
Arai, Takeshi Browse this author
Kumari, Parmila Browse this author
Hayakawa, Masaki Browse this author
Masuda, Chiaki Browse this author
Okada, Takashi Browse this author
Hara, Hiroshi Browse this author →KAKEN DB
Drucker, Daniel J. Browse this author
Yamada, Yuichiro Browse this author
Tokuda, Masaaki Browse this author
Yada, Toshihiko Browse this author
Issue Date: 2018
Journal Title: Nature Communications
Volume: 9
Issue: 1
Start Page: 113
Publisher DOI: 10.1038/s41467-017-02488-y
Abstract: Overeating and arrhythmic feeding promote obesity and diabetes. Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective anti-obesity drugs but their use is limited by side effects. Here we show that oral administration of the non-calorie sweetener, rare sugar D-allulose (D-psicose), induces GLP-1 release, activates vagal afferent signaling, reduces food intake and promotes glucose tolerance in healthy and obese-diabetic animal models. Subchronic D-allulose administered at the light period (LP) onset ameliorates LP-specific hyperphagia, visceral obesity, and glucose intolerance. These effects are blunted by vagotomy or pharmacological GLP-1R blockade, and by genetic inactivation of GLP-1R signaling in whole body or selectively in vagal afferents. Our results identify D-allulose as prominent GLP-1 releaser that acts via vagal afferents to restrict feeding and hyperglycemia. Furthermore, when administered in a time-specific manner, chronic D-allulose corrects arrhythmic overeating, obesity and diabetes, suggesting that chronotherapeutic modulation of vagal afferent GLP-1R signaling may aid in treating metabolic disorders.
Type: article
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 比良 徹

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