| Title: | GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose |
| Authors: | Iwasaki, Yusaku Browse this author |
| Sendo, Mio Browse this author |
| Dezaki, Katsuya Browse this author |
| Hira, Tohru Browse this author →KAKEN DB |
| Sato, Takehiro Browse this author |
| Nakata, Masanori Browse this author |
| Goswami, Chayon Browse this author |
| Aoki, Ryohei Browse this author |
| Arai, Takeshi Browse this author |
| Kumari, Parmila Browse this author |
| Hayakawa, Masaki Browse this author |
| Masuda, Chiaki Browse this author |
| Okada, Takashi Browse this author |
| Hara, Hiroshi Browse this author →KAKEN DB |
| Drucker, Daniel J. Browse this author |
| Yamada, Yuichiro Browse this author |
| Tokuda, Masaaki Browse this author |
| Yada, Toshihiko Browse this author |
| Issue Date: | 2018 |
| Journal Title: | Nature Communications |
| Volume: | 9 |
| Issue: | 1 |
| Start Page: | 113 |
| Publisher DOI: | 10.1038/s41467-017-02488-y |
| Abstract: | Overeating and arrhythmic feeding promote obesity and diabetes. Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective anti-obesity drugs but their use is limited by side effects. Here we show that oral administration of the non-calorie sweetener, rare sugar D-allulose (D-psicose), induces GLP-1 release, activates vagal afferent signaling, reduces food intake and promotes glucose tolerance in healthy and obese-diabetic animal models. Subchronic D-allulose administered at the light period (LP) onset ameliorates LP-specific hyperphagia, visceral obesity, and glucose intolerance. These effects are blunted by vagotomy or pharmacological GLP-1R blockade, and by genetic inactivation of GLP-1R signaling in whole body or selectively in vagal afferents. Our results identify D-allulose as prominent GLP-1 releaser that acts via vagal afferents to restrict feeding and hyperglycemia. Furthermore, when administered in a time-specific manner, chronic D-allulose corrects arrhythmic overeating, obesity and diabetes, suggesting that chronotherapeutic modulation of vagal afferent GLP-1R signaling may aid in treating metabolic disorders. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/84547 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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