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Resistant maltodextrin promotes fasting glucagon-like peptide-1 secretion and production together with glucose tolerance in rats
| Title: | Resistant maltodextrin promotes fasting glucagon-like peptide-1 secretion and production together with glucose tolerance in rats |
| Authors: | Hira, Tohru Browse this author →KAKEN DB | | Ikee, Asuka Browse this author | | Kishimoto, Yuka Browse this author | | Kanahori, Sumiko Browse this author | | Hara, Hiroshi Browse this author →KAKEN DB |
| Keywords: | Resistant maltodextrin | | Fructo-oligosaccharides | | Glucagon-like peptide-1 | | Glucose tolerance | | Proglucagon |
| Issue Date: | 2015 |
| Journal Title: | British Journal of Nutrition |
| Volume: | 114 |
| Issue: | 1 |
| Start Page: | 34 |
| End Page: | 42 |
| Publisher DOI: | 10.1017/S0007114514004322 |
| Abstract: | Glucagon-like peptide-1 (GLP-1), which is produced and released from enteroendocrine L cells, plays pivotal roles in postprandial glycaemia. The ingestion of resistant maltodextrin (RMD), a water-soluble non-digestible saccharide, improves the glycaemic response. In the present study, we examined whether the continuous feeding of RMD to rats affected GLP-1 levels and glycaemic control. Male Sprague-Dawley rats (6 weeks of age) were fed an American Institute of Nutrition (AIN)-93G-based diet containing either cellulose (5 %) as a control, RMD (2・5 or 5 %), or fructo-oligosaccharides (FOS, 2・5 or 5 %) for 7 weeks. During the test period, an intraperitoneal glucose tolerance test (IPGTT) was performed after 6 weeks. Fasting GLP-1 levels were significantly higher in the 5 % RMD group than in the control group after 6 weeks. The IPGTT results showed that the glycaemic response was lower in the 5 % RMD group than in the control group. Lower caecal pH, higher caecal tissue and content weights were observed in the RMD and FOS groups. Proglucagon mRNA levels were increased in the caecum and colon of both RMD and FOS groups, whereas caecal GLP-1 content was increased in the 5 % RMD group. In addition, a 1 h RMD exposure induced GLP-1 secretion in an enteroendocrine L-cell model, and single oral administration of RMD increased plasma GLP-1 levels in conscious rats. The present study demonstrates that continuous ingestion of RMD increased GLP-1 secretion and production in normal rats, which could be stimulated by its direct and indirect (enhanced gut fermentation) effects on GLP-1-producing cells, and contribute to improving glucose tolerance. |
| Rights: | Copyright © The Authors 2015 |
| Type: | article |
| URI: | http://hdl.handle.net/2115/84548 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 比良 徹
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