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Left ventricular mass index-to-QRS-voltage ratio predicts outcomes in heart failure with preserved ejection fraction

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Title: Left ventricular mass index-to-QRS-voltage ratio predicts outcomes in heart failure with preserved ejection fraction
Authors: Kinugasa, Yoshiharu Browse this author
Nakamura, Kensuke Browse this author
Kamitani, Hiroko Browse this author
Hirai, Masayuki Browse this author
Yanagihara, Kiyotaka Browse this author
Kato, Masahiko Browse this author
Nagai, Toshiyuki Browse this author
Yoshikawa, Tsutomu Browse this author
Saito, Yoshihiko Browse this author
Takeishi, Yasuchika Browse this author
Yamamoto, Kazuhiro Browse this author
Anzai, Toshihisa Browse this author →KAKEN DB
Keywords: Left ventricular mass
QRS voltage
Issue Date: Apr-2022
Publisher: Wiley Periodicals, Inc
Journal Title: ESC heart failure
Volume: 9
Issue: 2
Start Page: 1098
End Page: 1106
Publisher DOI: 10.1002/ehf2.13778
Abstract: Aims Increased left ventricular mass index (LVMI) disproportionate to electrocardiographic QRS voltage has been reported to be associated with cardiac fibrosis and amyloid infiltration to myocardium. This study aimed to assess whether the LVMI-toQRS-voltage ratio predicts clinical outcomes in heart failure with preserved ejection fraction (HFpEF). Methods and results The Japanese Heart Failure Syndrome with Preserved Ejection Fraction (JASPER) registry is a nationwide, observational, and prospective registration of Japanese patients hospitalized with HFpEF (EF >= 50%). LVMI was assessed by echocardiography using the cube formula. QRS voltage was assessed by Sokolow-Lyon voltage criteria. We divided 290 patients in the registry who met inclusion criteria into five groups according to the quintile values of their LVMI-to-QRS-voltage ratio. In the highest quintile group (>= 71.8 g/m(2)/mV), approximately 50% of the patients had concentric hypertrophy and 30% had eccentric hypertrophy. These patients had the highest proportion of atrial fibrillation (61.4%) and history of pacemaker implantation (12.1%) among the five groups (P < 0.05). During the mean follow-up of 587 +/- 300 days, 31.4% of all patients met the composite endpoint of all-cause death or rehospitalization for HF. Even after adjustment for demographic and baseline variables, the highest quintile group had a significantly higher incidence of the composite endpoints than the lowest quintile group (<30.7 g/m(2)/mV) (hazard ratio: 2.205, 95% confidence interval: 1.106-4.395, P < 0.05). Conclusions A high LVMI-to-QRS-voltage ratio is independently associated with poor outcomes in patients with HFpEF.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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