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Left ventricular mass index-to-QRS-voltage ratio predicts outcomes in heart failure with preserved ejection fraction
| Title: | Left ventricular mass index-to-QRS-voltage ratio predicts outcomes in heart failure with preserved ejection fraction |
| Authors: | Kinugasa, Yoshiharu Browse this author | | Nakamura, Kensuke Browse this author | | Kamitani, Hiroko Browse this author | | Hirai, Masayuki Browse this author | | Yanagihara, Kiyotaka Browse this author | | Kato, Masahiko Browse this author | | Nagai, Toshiyuki Browse this author | | Yoshikawa, Tsutomu Browse this author | | Saito, Yoshihiko Browse this author | | Takeishi, Yasuchika Browse this author | | Yamamoto, Kazuhiro Browse this author | | Anzai, Toshihisa Browse this author →KAKEN DB |
| Keywords: | Left ventricular mass | | QRS voltage | | Amyloidosis | | HFpEF |
| Issue Date: | Apr-2022 |
| Publisher: | Wiley Periodicals, Inc |
| Journal Title: | ESC heart failure |
| Volume: | 9 |
| Issue: | 2 |
| Start Page: | 1098 |
| End Page: | 1106 |
| Publisher DOI: | 10.1002/ehf2.13778 |
| Abstract: | Aims Increased left ventricular mass index (LVMI) disproportionate to electrocardiographic QRS voltage has been reported to be associated with cardiac fibrosis and amyloid infiltration to myocardium. This study aimed to assess whether the LVMI-toQRS-voltage ratio predicts clinical outcomes in heart failure with preserved ejection fraction (HFpEF). Methods and results The Japanese Heart Failure Syndrome with Preserved Ejection Fraction (JASPER) registry is a nationwide, observational, and prospective registration of Japanese patients hospitalized with HFpEF (EF >= 50%). LVMI was assessed by echocardiography using the cube formula. QRS voltage was assessed by Sokolow-Lyon voltage criteria. We divided 290 patients in the registry who met inclusion criteria into five groups according to the quintile values of their LVMI-to-QRS-voltage ratio. In the highest quintile group (>= 71.8 g/m(2)/mV), approximately 50% of the patients had concentric hypertrophy and 30% had eccentric hypertrophy. These patients had the highest proportion of atrial fibrillation (61.4%) and history of pacemaker implantation (12.1%) among the five groups (P < 0.05). During the mean follow-up of 587 +/- 300 days, 31.4% of all patients met the composite endpoint of all-cause death or rehospitalization for HF. Even after adjustment for demographic and baseline variables, the highest quintile group had a significantly higher incidence of the composite endpoints than the lowest quintile group (<30.7 g/m(2)/mV) (hazard ratio: 2.205, 95% confidence interval: 1.106-4.395, P < 0.05). Conclusions A high LVMI-to-QRS-voltage ratio is independently associated with poor outcomes in patients with HFpEF. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/84564 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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