HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >

Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin
Authors: Harada, Naoki Browse this author
Okuyama, Mai Browse this author
Teraoka, Yoshiaki Browse this author
Arahori, Yumi Browse this author
Shinmori, Yoh Browse this author
Horiuchi, Hiroko Browse this author
Luis, Paula B. Browse this author
Joseph, Akil I. Browse this author
Kitakaze, Tomoya Browse this author
Matsumura, Shigenobu Browse this author
Hira, Tohru Browse this author →KAKEN DB
Yamamoto, Norio Browse this author
Iuni, Takashi Browse this author
Goshima, Naoki Browse this author
Schneider, Claus Browse this author
Inui, Hiroshi Browse this author
Yamaji, Ryoichi Browse this author
Issue Date: 2022
Journal Title: npj Science of Food
Volume: 6
Issue: 1
Start Page: 4
Publisher DOI: 10.1038/s41538-021-00119-x
Abstract: The identification of molecular targets of bioactive food components is important to understand the mechanistic aspect of their physiological functions. Here, we have developed a screening system that enables us to determine the activation of G protein-coupled receptors (GPCRs) by food components and have identified GPR55 as a target for curcumin. Curcumin activated GPR55 and induced serum-response element- and serum-response factor-mediated transcription, which were inhibited by Rho kinase and GPR55 antagonists. Both the methoxy group and the heptadienone moiety of curcumin were required for GPR55 activation. The F1905.47 residue of GPR55 was important for the interaction with curcumin. The curcumin-induced secretion of glucagon-like peptide-1 in GLUTag cells was inhibited by a GPR55 antagonist. These results indicate that expression screening is a useful system to identify GPCRs as targets of food components and strongly suggest that curcumin activates GPR55 as an agonist, which is involved in the physiological function of curcumin.
Type: article
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University