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Prenatal exposure to 11 perfluoroalkyl substances and fetal growth : A large-scale, prospective birth cohort study

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Title: Prenatal exposure to 11 perfluoroalkyl substances and fetal growth : A large-scale, prospective birth cohort study
Authors: Kashino, Ikuko Browse this author
Sasaki, Seiko Browse this author →KAKEN DB
Okada, Emiko Browse this author
Matsuura, Hideyuki Browse this author
Goudarzi, Houman Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Okada, Eisaku Browse this author
Ito, Yoichi M. Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Birth weight
Perfluoroalkyl substances (PFAS)
Perfluorononanoic acid (PFNA)
Perfluorooctane sulfonate (PFOS)
Perfluorooctanoic acid (PFOA)
Issue Date: Mar-2020
Publisher: Elsevier
Journal Title: Environment International
Volume: 136
Start Page: 105355
Publisher DOI: 10.1016/j.envint.2019.105355
Abstract: Background:Prenatal maternal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)has been reportedly associated with decreased birth weight. Although a majority of epidemiological studiesconcerning perfluoroalkyl substances (PFAS) have focused on PFOS and PFOA, epidemiological studies of PFASwith longer carbon chains are scarce. In this study, we investigated whether prenatal maternal exposure to 11PFAS, in particular those with longer carbon chains, is associated with fetal growth.Methods:The study included 1985 mother-infant pairs (inclusive of preterm and post-term infants), who en-rolled in a large-scale, prospective birth cohort study in any of the 37 hospitals in Hokkaido, Japan between2003 and 2009. The concentration of 11 PFAS was measured in maternal plasma collected during the thirdtrimester of pregnancy, using ultra-performance liquid chromatography in combination with triple quadrupolemass spectrometry. Associations between the measured PFAS values and weight, length, and head circumferenceof all newborns at birth were examined using multiple regression analyses with adjustment for potential con-founders based on data collected from medical records, questionnaires, and those for maternal plasma samples.Results:Of the 11 PFAS analyzed, prenatal perfluorononanoic acid (PFNA) [per log10-unit: regression coefficient(β) = −96.2 g, 95% confidence intervals (95% CI), −165.3 to −27.1] and perfluorodecanoic acid (PFDA)(β = −72.2 g, 95% CI, −138.1 to −6.3) concentrations were inversely associated with birth weight.Furthermore, PFNA concentrations were inversely associated with birth length (per Log10unit: β = −0.48 cm,95% CI; − 0.86 to −0.11). Maternal perfluorotridecanoic acid (PFTrDA) exposure showed a significant inverseassociation with birth weight only for female infants (per Log10unit: β = −99.8 g, 95% CI, − 193.7 to −6.0) (Pfor interaction = 0.04).Conclusions:Our findings suggest that prenatal, maternal exposure to PFAS with longer carbon chains tends tobe inversely associated with birth size of newborn infants, which may indicate that these commercially usedcompounds have an adverse effect on fetal growth.
Type: article
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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