| Title: | Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions : a cross-sectional study |
| Authors: | Jia, Xiaofang Browse this author |
| Tagawa, Masahiro Browse this author |
| Yatsuya, Hiroshi Browse this author |
| Naito, Hisao Browse this author |
| Hayashi, Yumi Browse this author |
| Yetti, Husna Browse this author |
| Sasaki, Seiko Browse this author →KAKEN DB |
| Araki, Atsuko Browse this author →KAKEN DB |
| Miyashita, Chihiro Browse this author →KAKEN DB |
| Ikeno, Tamiko Browse this author →KAKEN DB |
| Kishi, Reiko Browse this author →KAKEN DB |
| Nakajima, Tamie Browse this author |
| Keywords: | Association study |
| fatty acid status |
| pregnancy |
| term birth outcomes |
| Issue Date: | 1-Sep-2015 |
| Publisher: | De Gruyter |
| Journal Title: | Journal of Perinatal Medicine |
| Volume: | 43 |
| Issue: | 5 |
| Start Page: | 565 |
| End Page: | 575 |
| Publisher DOI: | 10.1515/jpm-2014-0277 |
| Abstract: | Objective: To investigate selected fatty acid (FA) profiles in maternal whole blood during normal pregnancy and to evaluate their associations with term birth dimensions.
Methods: We characterized nine major maternal blood FAs representing four FA families during the second and third trimester of pregnancy, and explored their associations with birth weight, length, and chest or head circumferences by multivariate regression models, using data from 318 mother-newborn pairs of the Hokkaido Study.
Results: The absolute and/or relative contents of maternal blood docosahexaenoic acid and arachidonic acid were lowest at 35–41 gestational weeks during pregnancy, as was the essential FA status index. Different from palmitic and stearic acids, palmitoleic and oleic acid contents were higher at 35–41 gestational weeks than those at 23–31 gestational weeks. Three FA components were identified through principal component analysis, and were used in association analysis. Component 3, which was positively and significantly loaded by eicosapentaenoic acid (EPA), was associated with chest circumference [β=0.281, 95% confidence interval (CI): 0.006, 0.556] at 35–41 gestational weeks (P=0.046). No significant associations were observed for Component 1 and 2 loaded by FAs except EPA.
Conclusion: Maternal blood EPA content may have an important influence on infant chest circumference. |
| Rights: | The final publication is available at www.degruyter.com |
| Type: | article |
| URI: | http://hdl.handle.net/2115/84613 |
| Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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