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Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions : a cross-sectional study

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Title: Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions : a cross-sectional study
Authors: Jia, Xiaofang Browse this author
Tagawa, Masahiro Browse this author
Yatsuya, Hiroshi Browse this author
Naito, Hisao Browse this author
Hayashi, Yumi Browse this author
Yetti, Husna Browse this author
Sasaki, Seiko Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Ikeno, Tamiko Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Nakajima, Tamie Browse this author
Keywords: Association study
fatty acid status
term birth outcomes
Issue Date: 1-Sep-2015
Publisher: De Gruyter
Journal Title: Journal of Perinatal Medicine
Volume: 43
Issue: 5
Start Page: 565
End Page: 575
Publisher DOI: 10.1515/jpm-2014-0277
Abstract: Objective: To investigate selected fatty acid (FA) profiles in maternal whole blood during normal pregnancy and to evaluate their associations with term birth dimensions. Methods: We characterized nine major maternal blood FAs representing four FA families during the second and third trimester of pregnancy, and explored their associations with birth weight, length, and chest or head circumferences by multivariate regression models, using data from 318 mother-newborn pairs of the Hokkaido Study. Results: The absolute and/or relative contents of maternal blood docosahexaenoic acid and arachidonic acid were lowest at 35–41 gestational weeks during pregnancy, as was the essential FA status index. Different from palmitic and stearic acids, palmitoleic and oleic acid contents were higher at 35–41 gestational weeks than those at 23–31 gestational weeks. Three FA components were identified through principal component analysis, and were used in association analysis. Component 3, which was positively and significantly loaded by eicosapentaenoic acid (EPA), was associated with chest circumference [β=0.281, 95% confidence interval (CI): 0.006, 0.556] at 35–41 gestational weeks (P=0.046). No significant associations were observed for Component 1 and 2 loaded by FAs except EPA. Conclusion: Maternal blood EPA content may have an important influence on infant chest circumference.
Rights: The final publication is available at
Type: article
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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