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Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration : A Review

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Title: Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration : A Review
Authors: Ohnishi, Takashi Browse this author
Iwasaki, Norimasa Browse this author →KAKEN DB
Sudo, Hideki Browse this author →KAKEN DB
Keywords: intervertebral disc degeneration
small interfering RNA (siRNA)
microRNA (miR)
long non-coding RNA (lncRNA)
circular RNA (circRNA)
Issue Date: Feb-2022
Publisher: MDPI
Journal Title: Cells
Volume: 11
Issue: 3
Start Page: 394
Publisher DOI: 10.3390/cells11030394
Abstract: Intervertebral disc degeneration (IVDD) is a pathological condition that can lead to intractable back pain or secondary neurological deficits. There is no fundamental cure for this condition, and current treatments focus on alleviating symptoms indirectly. Numerous studies have been performed to date, and the major strategy for all treatments of IVDD is to prevent cell loss due to programmed or regulated cell death. Accumulating evidence suggests that several types of cell death other than apoptosis, including necroptosis, pyroptosis, and ferroptosis, are also involved in IVDD. In this study, we discuss the molecular pathway of each type of cell death and review the literature that has identified their role in IVDD. We also summarize the recent advances in targeted therapy at the RNA level, including RNA modulations through RNA interference and regulation of non-coding RNAs, for preventing cell death and subsequent IVDD. Therefore, we review the causes and possible therapeutic targets for RNA intervention and discuss the future direction of this research field.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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