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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration : A Review
| Title: | Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration : A Review |
| Authors: | Ohnishi, Takashi Browse this author | | Iwasaki, Norimasa Browse this author →KAKEN DB | | Sudo, Hideki Browse this author →KAKEN DB |
| Keywords: | intervertebral disc degeneration | | apoptosis | | necroptosis | | pyroptosis | | ferroptosis | | small interfering RNA (siRNA) | | microRNA (miR) | | long non-coding RNA (lncRNA) | | circular RNA (circRNA) |
| Issue Date: | Feb-2022 |
| Publisher: | MDPI |
| Journal Title: | Cells |
| Volume: | 11 |
| Issue: | 3 |
| Start Page: | 394 |
| Publisher DOI: | 10.3390/cells11030394 |
| Abstract: | Intervertebral disc degeneration (IVDD) is a pathological condition that can lead to intractable back pain or secondary neurological deficits. There is no fundamental cure for this condition, and current treatments focus on alleviating symptoms indirectly. Numerous studies have been performed to date, and the major strategy for all treatments of IVDD is to prevent cell loss due to programmed or regulated cell death. Accumulating evidence suggests that several types of cell death other than apoptosis, including necroptosis, pyroptosis, and ferroptosis, are also involved in IVDD. In this study, we discuss the molecular pathway of each type of cell death and review the literature that has identified their role in IVDD. We also summarize the recent advances in targeted therapy at the RNA level, including RNA modulations through RNA interference and regulation of non-coding RNAs, for preventing cell death and subsequent IVDD. Therefore, we review the causes and possible therapeutic targets for RNA intervention and discuss the future direction of this research field. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/84687 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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