HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >

Metabolomic Alteration in the Plasma of Wild Rodents Environmentally Exposed to Lead : A Preliminary Study

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: Metabolomic Alteration in the Plasma of Wild Rodents Environmentally Exposed to Lead : A Preliminary Study
Authors: Nakata, Hokuto Browse this author →KAKEN DB
Eguchi, Akifumi Browse this author
Nakayama, Shouta M. M. Browse this author →KAKEN DB
Yabe, John Browse this author
Muzandu, Kaampwe Browse this author
Ikenaka, Yoshinori Browse this author →KAKEN DB
Mori, Chisato Browse this author
Ishizuka, Mayumi Browse this author →KAKEN DB
Keywords: lead
wild rodent
biological pathway
lasso regression model
random forest model
Issue Date: Jan-2022
Publisher: MDPI
Journal Title: International journal of environmental research and public health
Volume: 19
Issue: 1
Start Page: 541
Publisher DOI: 10.3390/ijerph19010541
Abstract: Lead poisoning is often considered a traditional disease; however, the specific mechanism of toxicity remains unclear. The study of Pb-induced alterations in cellular metabolic pathways is important to understand the biological response and disorders associated with environmental exposure to lead. Metabolomics studies have recently been paid considerable attention to understand in detail the biological response to lead exposure and the associated toxicity mechanisms. In the present study, wild rodents collected from an area contaminated with lead (N = 18) and a control area (N = 10) were investigated. This was the first ever experimental metabolomic study of wildlife exposed to lead in the field. While the levels of plasma phenylalanine and isoleucine were significantly higher in a lead-contaminated area versus the control area, hydroxybutyric acid was marginally significantly higher in the contaminated area, suggesting the possibility of enhancement of lipid metabolism. In the interregional least-absolute shrinkage and selection operator (lasso) regression model analysis, phenylalanine and isoleucine were identified as possible biomarkers, which is in agreement with the random forest model. In addition, in the random forest model, glutaric acid, glutamine, and hydroxybutyric acid were selected. In agreement with previous studies, enrichment analysis showed alterations in the urea cycle and ATP-binding cassette transporter pathways. Although regional rodent species bias was observed in this study, and the relatively small sample size should be taken into account, the present results are to some extent consistent with those of previous studies on humans and laboratory animals.
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University