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Disordered Expression of HOX Genes in Human Non-Small Cell Lung Cancer

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Title: Disordered Expression of HOX Genes in Human Non-Small Cell Lung Cancer
Authors: Abe, Motoki Browse this author
Hamada, Jun-ichi Browse this author
Takahashi, Osamu Browse this author
Takahashi, Yoko Browse this author
Tada, Mitsuhiro Browse this author
Miyamoto, Masaki Browse this author
Morikawa, Toshiaki Browse this author
Kondo, Satoshi Browse this author →KAKEN DB
Moriuchi, Tetsuya Browse this author
Keywords: Homeobox gene
Real-time RT-PCR
Lung cancer
Issue Date: Apr-2006
Volume: 15
Issue: 4
Start Page: 797
End Page: 802
Abstract: We hypothesized that the disordered tissue architecture in cancer results from the steps that the cells execute the program designed during ontogeny in a spatiotemporally inappropriate manner. HOX genes are known as master regulators of embryonic morphogenesis, and encode transcription factors which regulate the transcription of the downstream genes to realize the program of body plan. In this study, we quantified the expression levels of 39 HOX genes in 41 human non-small cell lung cancer (non-SCLC) and non-cancerous lung tissues by a comprehensive analysis system based on the realtime RT-PCR method. We found that the expression levels of HOXA1, A5, A10 and C6 in squamous cell carcinoma tissues (and HOXA5 and A10 in adenocarcinoma tissues) were significantly higher than those in the non-cancerous tissues. Comparison of HOX gene expressions between adenocarcinoma and squamous cell carcinoma tissues showed higher expressions of HOXA1, D9, D10 and D11 in squamous cell carcinoma tissues than in adenocarcinoma tissues. Immunohistochemical analysis revealed that HOXA5 and A10 proteins were localized in the cytoplasm of tumor cells in both adenocarcinoma and squamous cell carcinoma tissues. These results suggest that the disordered patterns of HOX gene expressions were involved in not only the development of non-SCLC but also histological diversity such as adenocarcinoma and squamous cell carcinoma.
Type: article
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 浜田 淳一

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