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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
Controlled release, antimicrobial activity, and oral mucosa irritation of cetylpyridinium chloride-montmorillonite incorporated in a tissue conditioner
| Title: | Controlled release, antimicrobial activity, and oral mucosa irritation of cetylpyridinium chloride-montmorillonite incorporated in a tissue conditioner |
| Authors: | Asahara, Erika Browse this author | | Abe, Yasuhiko Browse this author →KAKEN DB | | Nakamori, Kiichi Browse this author | | Okazaki, Yohei Browse this author →KAKEN DB | | Makita, Yoji Browse this author →KAKEN DB | | Hasebe, Akira Browse this author →KAKEN DB | | Tsuga, Kazuhiro Browse this author →KAKEN DB | | Yokoyama, Atsuro Browse this author →KAKEN DB |
| Keywords: | Tissue conditioner | | Cetylpyridinium chloride (CPC) | | Release test | | Antimicrobial | | Oral mucosa irritation |
| Issue Date: | 1-Feb-2022 |
| Publisher: | 日本歯科理工学会(The Japanese Society for Dental Materials and Devices) |
| Journal Title: | Dental materials journal |
| Volume: | 41 |
| Issue: | 1 |
| Start Page: | 142 |
| End Page: | 149 |
| Publisher DOI: | 10.4012/dmj.2021-155 |
| PMID: | 34556596 |
| Abstract: | This study examined the controlled release of cetylpyridinium chloride (CPC) from a tissue conditioner (TC) containing CPC-montmorillonite (CPC-Mont), the associated antimicrobial activity, and oral mucosa irritation. The CPC release test was performed daily for 28 days in three test solutions: distilled water, 0.2 M NaCl, and 0.2 M HCl. The antimicrobial activities for 7, 14, 21, and 28 days against Candida albicans, Staphylococcus aureus, and Streptococcus mutans were assessed according to the JIS Z 2801/ISO 22196 standard. An oral mucosa irritation test was conducted using cheek pouches in five male hamsters according to the ISO 1099310:2010 standard. The amount of CPC released each day and the cumulative amount released over 28 days (6.12 mg) were less than the daily safe maximum of sore throat medicines (8 mg). Additionally, TC with CPC-Mont could sustain antimicrobial activity against adherent bacteria for 14 days and has no oral mucosa irritation potential. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/85083 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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