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Secretion of GLP-1 but not GIP is potently stimulated by luminal d -Allulose ( d -Psicose) in rats
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| Title: | Secretion of GLP-1 but not GIP is potently stimulated by luminal d -Allulose ( d -Psicose) in rats |
| Authors: | Hayakawa, Masaki Browse this author | | Hira, Tohru Browse this author →KAKEN DB | | Nakamura, Masako Browse this author | | Iida, Tetsuo Browse this author | | Kishimoto, Yuka Browse this author | | Hara, Hiroshi Browse this author →KAKEN DB |
| Keywords: | GLP-1 | | GIP | | Allulose |
| Issue Date: | 12-Feb-2018 |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 496 |
| Issue: | 3 |
| Start Page: | 898 |
| End Page: | 903 |
| Publisher DOI: | 10.1016/j.bbrc.2018.01.128 |
| Abstract: | Glucagon-like peptide 1 (GLP-1), an incretin gastrointestinal hormone, is secreted when stimulated by nutrients including metabolizable sugars such as glucose and fructose. d-Allulose (allulose), also known as d-psicose, is a C-3 isomer of d-fructose and a rare sugar with anti-diabetic or anti-obese effects in animal models. In the present study, we examined whether an oral administration of allulose could stimulate GLP-1 secretion in rats, and investigated the underlying mechanisms. Oral, but not intraperitoneal, administration of allulose (0.5?2.0?g/kg body weight) elevated plasma GLP-1 levels for more than 2?h in a dose-dependent manner. The effects of allulose on GLP-1 secretion were higher than that of dextrin, fructose, or glucose. In addition, oral allulose increased total and active GLP-1, but not glucose-dependent insulinotropic polypeptide (GIP), levels in the portal vein. In anesthetized rats equipped with a portal catheter, luminal (duodenum and ileum) administration of allulose increased portal GLP-1 levels, indicating the luminal effect of allulose. Allulose-induced GLP-1 secretion was abolished in the presence of xanthohumol (a glucose/fructose transport inhibitor), but not in the presence of inhibitors of the sodium-dependent glucose cotransporter 1 or the sweet taste receptor. These results demonstrate a potent and lasting effect of orally administered allulose on GLP-1 secretion in rats, without affecting GIP secretion. The potent and selective GLP-1-releasing effect of allulose holds promise for the prevention and treatment of glucose intolerance through promoting endogenous GLP-1 secretion. |
| Rights: | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/85108 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 比良 徹
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