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Wheat gluten hydrolysate potently stimulates peptide-YY secretion and suppresses food intake in rats
| Title: | Wheat gluten hydrolysate potently stimulates peptide-YY secretion and suppresses food intake in rats |
| Authors: | Chen, Wenya Browse this author | | Hira, Tohru Browse this author →KAKEN DB | | Nakajima, Shingo Browse this author | | Hara, Hiroshi Browse this author →KAKEN DB |
| Keywords: | Protein hydrolysate | | gut satiety hormone | | food intake | | enteroendocrine cell |
| Issue Date: | 2018 |
| Journal Title: | Bioscience, Biotechnology, and Biochemistry |
| Volume: | 82 |
| Issue: | 11 |
| Start Page: | 1992 |
| End Page: | 1999 |
| Publisher DOI: | 10.1080/09168451.2018.1505482 |
| Abstract: | The study was aimed to compare the satiating effect of various protein hydrolysates in rats and examine the underlying mechanism associated with the satiety hormones. Food intake and portal satiety hormone levels were measured in rats. Enteroendocrine cell-lines were employed to study the direct effect of protein hydrolysates on gut hormone secretions. The results showed that oral preload of wheat gluten hydrolysate (WGH) suppressed food intake greater and longer than other hydrolysates. The portal peptide-YY levels in WGH-treated rats at 2 h and 3 h were higher than those in control- and lactalbumin hydrolysate (LAH)-treated rats. In a distal enteroendocrine cell model, WGH more potently stimulated glucagon-like peptide-1 secretion than LAH, and the effect was largely enhanced by pepsin/pancreatin digestion of WGH. These results suggest WGH is potent in activating enteroendocrine cells to release satiety hormones leading to the prolonged suppression of food intake. |
| Rights: | This is a pre-copyedited, author-produced version of an article accepted for publication in Bioscience biotechnology and biochemistry following peer review. The version of record Wenya Chen, Tohru Hira, Shingo Nakajima, Hiroshi Hara, Wheat gluten hydrolysate potently stimulates peptide-YY secretion and suppresses food intake in rats, Bioscience, Biotechnology, and Biochemistry, Volume 82, Issue 11, 2 November 2018, Pages 1992-1999 is available online at: https://doi.org/10.1080/09168451.2018.1505482. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/85125 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 比良 徹
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