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Altered regulation of mesenchymal cell senescence in adipose tissue promotes pathological changes associated with diabetic wound healing
| Title: | Altered regulation of mesenchymal cell senescence in adipose tissue promotes pathological changes associated with diabetic wound healing |
| Authors: | Kita, Arisa Browse this author →KAKEN DB | | Saito, Yuki Browse this author →KAKEN DB | | Miura, Norihiro Browse this author | | Miyajima, Maki Browse this author →KAKEN DB | | Yamamoto, Sena Browse this author | | Sato, Tsukasa Browse this author | | Yotsuyanagi, Takatoshi Browse this author →KAKEN DB | | Fujimiya, Mineko Browse this author →KAKEN DB | | Chikenji, Takako S. Browse this author →KAKEN DB |
| Issue Date: | 5-Apr-2022 |
| Publisher: | Nature Portfolio |
| Journal Title: | Communications biology |
| Volume: | 5 |
| Issue: | 1 |
| Start Page: | 310 |
| Publisher DOI: | 10.1038/s42003-022-03266-3 |
| PMID: | 35383267 |
| Abstract: | Pathologic diabetic wound healing is caused by sequential and progressive deterioration of hemostasis, inflammation, proliferation, and resolution/remodeling. Cellular senescence promotes wound healing; however, diabetic wounds exhibit low levels of senescent factors and accumulate senescent cells, which impair the healing process. Here we show that the number of p15(INK4B) + PDGFR alpha + senescent mesenchymal cells in adipose tissue increases transiently during early phases of wound healing in both non-diabetic mice and humans. Transplantation of adipose tissue from diabetic mice into non-diabetic mice results in impaired wound healing and an altered cellular senescence-associated secretory phenotype (SASP), suggesting that insufficient induction of adipose tissue senescence after injury is a pathological mechanism of diabetic wound healing. These results provide insight into how regulation of senescence in adipose tissue contributes to wound healing and could constitute a basis for developing therapeutic treatment for wound healing impairment in diabetes. Type-2 diabetic adipose tissue impairs transient senescence during wound healing with expression of different components of the senescence-associated secretory phenotype (SASP), and this is associated with deteriorated wound healing. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/85172 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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