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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet
| Title: | Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet |
| Authors: | Hira, Tohru Browse this author →KAKEN DB | | Yanagihara, Kurumi Browse this author | | Koga, Toshiki Browse this author | | Takahashi, Keisuke Browse this author | | Nagura, Taizo Browse this author | | Uchino, Hirokatsu Browse this author | | Hara, Hiroshi Browse this author →KAKEN DB |
| Keywords: | difructose anhydride III | | raffinose | | fructooligosaccharides | | diet-induced obesity | | GLP-1 |
| Issue Date: | 2017 |
| Journal Title: | Bioscience, Biotechnology and Biochemistry |
| Volume: | 81 |
| Issue: | 11 |
| Start Page: | 2186 |
| End Page: | 2194 |
| Publisher DOI: | 10.1080/09168451.2017.1373591 |
| Abstract: | We investigated the effects of dietary supplementation of difructose anhydride III (DFA III), raffinose (Raf), and fructooligosaccharides (FOS) on diet-induced obesity development. Male rats were fed normal or high-fat and high-sucrose (HFS) diet, with or without supplementing (3%) DFA III, Raf, or FOS, for 8 or 5 weeks. Supplementing DFA III to the HFS diet decreased energy intake compared to the non-supplemented HFS diet. Accordingly, body weight gain and fat accumulation reduced in DFA III-fed rats. Cecal acetate production and plasma glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY) were elevated in DFA III-fed rats, while Raf and FOS partially affected these parameters. These results demonstrate that DFA III has suppressive effect on excessive energy intake driven by the palatable obesogenic diet, possibly due to combined effects of increased anorexigenic factors such as cecal acetate production and GLP-1/PYY secretion. |
| Rights: | This is a pre-copyedited, author-produced version of an article accepted for publication in Bioscience biotechnology and biochemistry following peer review. The version of record Tohru Hira, Kurumi Yanagihara, Toshiki Koga, Keisuke Takahashi, Taizo Nagura, Hirokatsu Uchino, Hiroshi Hara, Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet, Bioscience, Biotechnology, and Biochemistry, Volume 81, Issue 11, 2 November 2017, Pages 2186–2194 is available online at: https://doi.org/10.1080/09168451.2017.1373591. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/85186 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 比良 徹
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