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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Suppressive Effect on Food Intake of a Potato Extract (Potein®) Involving Cholecystokinin Release in Rats
| Title: | Suppressive Effect on Food Intake of a Potato Extract (Potein®) Involving Cholecystokinin Release in Rats |
| Authors: | CHEN, Wenya Browse this author | | HIRA, Tohru Browse this author →KAKEN DB | | NAKAJIMA, Shingo Browse this author | | TOMOZAWA, Hiroshi Browse this author | | TSUBATA, Masahito Browse this author | | YAMAGUCHI, Kazuya Browse this author | | HARA, Hiroshi Browse this author →KAKEN DB |
| Keywords: | potato extract | | cholecystokinin | | appetite | | rat | | devazepide |
| Issue Date: | 2012 |
| Journal Title: | Bioscience, Biotechnology and Biochemistry |
| Volume: | 76 |
| Issue: | 6 |
| Start Page: | 1104 |
| End Page: | 1109 |
| Publisher DOI: | 10.1271/bbb.110936 |
| Abstract: | We have recently reported that oral gavage of a potato extract (Potein®) suppressed the food intake in rats. The satiating effect of the potato extract was compared in the present study to other protein sources, and the involvement of endogenous cholecystokinin (CCK) secretion was examined. Food consumption was measured in 18-h fasted rats after oral gavage of the potato extract or other protein sources. The CCK-releasing activity of the potato extract was then examined in anesthetized rats with a portal cannula. Oral gavage of the potato extract reduced the food intake in the rats, the effect being greater than with casein and a soybean β-conglycinin hydrolysate. The suppressive effect on appetite of the potato extract was attenuated by treating with a CCK-receptor antagonist (devazepide). The portal CCK concentration was increased after a duodenal administration of the potato extract to anesthetized rats. These results indicate that the potato extract suppressed the food intake in rats through CCK secretion. |
| Rights: | This is a pre-copyedited, author-produced version of an article accepted for publication in Bioscience biotechnology and biochemistry following peer review. The version of record Wenya CHEN, Tohru HIRA, Shingo NAKAJIMA, Hiroshi TOMOZAWA, Masahito TSUBATA, Kazuya YAMAGUCHI, Hiroshi HARA, Suppressive Effect on Food Intake of a Potato Extract (PoteinR) Involving Cholecystokinin Release in Rats, Bioscience, Biotechnology, and Biochemistry, Volume 76, Issue 6, 23 June 2012, Pages 1104-1109 is available online at: https://doi.org/10.1271/bbb.110936. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/85201 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 比良 徹
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