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High-grade neuroepithelial tumor with BCL6 corepressor-alteration presenting pathological and radiological calcification: A case report
| Title: | High-grade neuroepithelial tumor with BCL6 corepressor-alteration presenting pathological and radiological calcification: A case report |
| Authors: | Ishi, Yukitomo Browse this author →KAKEN DB | | Shimizu, Ai Browse this author | | Takakuwa, Emi Browse this author | | Sugiyama, Minako Browse this author | | Okamoto, Michinari Browse this author | | Motegi, Hiroaki Browse this author | | Hirabayashi, Shinsuke Browse this author | | Cho, Yuko Browse this author | | Iguchi, Akihiro Browse this author | | Manabe, Atsushi Browse this author | | Nobusawa, Sumihito Browse this author | | Tanaka, Shinya Browse this author | | Yamaguchi, Shigeru Browse this author |
| Keywords: | BCOR | | high-grade neuroepithelial tumor | | pediatric | | PNET |
| Issue Date: | May-2021 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Pathology international |
| Volume: | 71 |
| Issue: | 5 |
| Start Page: | 348 |
| End Page: | 354 |
| Publisher DOI: | 10.1111/pin.13083 |
| Abstract: | A 5-year-old girl presented with headache and vomiting. Head computed tomography and magnetic resonance imaging showed a right frontal lobe tumor with marked calcification. The patient underwent resection surgery with suspicion of anaplastic ependymoma, and the tumor was gross totally removed. Pathological examination revealed areas of dense tumor cells with a high nucleocytoplasmic ratio and myxoid areas consisting of tumor cells with a round-shaped nucleus and eosinophilic cytoplasm. Perivascular pseudorosette, necrosis, circumscribed growth, and microcalcification were also observed. Immunohistochemistry demonstrated negative staining for glial fibrillary protein and epithelial membrane antigen. Diagnosis of a high-grade neuroepithelial tumor (HGNET) with BCL6 corepressor (BCOR) alteration was made based on pathological findings and internal tandem duplication in the exon 15 of BCOR. Although calcification on radiological and pathological examination is not typical, it would be essential to recognize that calcification could appear in HGNET-BCOR. |
| Rights: | This is the peer reviewed version of the following article: Ishi, Y., Shimizu, A., Takakuwa, E., Sugiyama, M., Okamoto, M., Motegi, H., Hirabayashi, S., Cho, Y., Iguchi, A., Manabe, A., Nobusawa, S., Tanaka, S. and Yamaguchi, S. (2021), High-grade neuroepithelial tumor with BCL6 corepressor-alteration presenting pathological and radiological calcification: A case report. Pathology International, 71: 348-354, which has been published in final form at https://doi.org/10.1111/PIN.13083. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/85210 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 伊師 雪友
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