| Title: | High lymphocyte counts before antithymocyte globulin administration predict acute graft-versus-host disease |
| Authors: | Shiratori, Souichi Browse this author →KAKEN DB |
| Ohigashi, Hiroyuki Browse this author →KAKEN DB |
| Ara, Takahide Browse this author |
| Yasumoto, Atsushi Browse this author →KAKEN DB |
| Goto, Hideki Browse this author →KAKEN DB |
| Nakagawa, Masao Browse this author →KAKEN DB |
| Sugita, Junichi Browse this author |
| Onozawa, Masahiro Browse this author →KAKEN DB |
| Kahata, Kaoru Browse this author |
| Endo, Tomoyuki Browse this author |
| Hashimoto, Daigo Browse this author →KAKEN DB |
| Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | Allogeneic hematopoietic stem cell transplantation |
| Peripheral blood stem cell transplantation |
| Antithymocyte globulin |
| Graft-versus-host disease |
| Absolute lymphocyte count |
| Issue Date: | May-2021 |
| Publisher: | Springer |
| Journal Title: | Annals of hematology |
| Volume: | 100 |
| Issue: | 5 |
| Start Page: | 1321 |
| End Page: | 1328 |
| Publisher DOI: | 10.1007/s00277-020-04347-1 |
| Abstract: | Antithymocyte globulin (ATG) reduces severe acute and chronic graft-versus-host disease (GVHD) in allogeneic peripheral blood stem cell transplantation (PBSCT). However, risk factors for severe acute GVHD in PBSCT using ATG remain to be determined. We conducted a single-center, retrospective study to analyze the association of acute GVHD requiring systemic corticosteroid (SC-aGVHD) with absolute lymphocyte counts (ALC) before the administration of ATG or conditioning in 53 patients with HLA-matched PBSCT using low-dose thymoglobulin (2 mg/kg) after myeloablative conditioning. The cumulative incidence of SC-aGVHD was 17.0% and ALC before ATG were significantly higher in patients with SC-aGVHD compared to that in patients without it (median, 0.15 x 10(9)/L vs 0.06 x 10(9)/L, P = 0.047). The cumulative incidence of SC-aGVHD was significantly higher in patients with high ALC before ATG (>= 0.15 x 10(9)/L) than in those with low ALC (38.5% vs 10.0%, P = 0.016). Non-relapse mortality (NRM) was also significantly higher in the high ALC before ATG group than the low ALC before ATG group (2-year NRM: 23.9% vs 6.0%, P = 0.048), leading to worse survival (2-year overall survival: 69.2% vs 83.5%, P = 0.039). Our study suggested that high ALC before ATG is a risk factor for SC-aGVHD. |
| Rights: | This is a post-peer-review, pre-copyedit version of an article published in Annals of Hematology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00277-020-04347-1 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/85245 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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