| Title: | Morphological features of macular telangiectasia type 2 in Japanese patients |
| Authors: | Shinkai, Akihiro Browse this author |
| Saito, Wataru Browse this author →KAKEN DB |
| Hashimoto, Yuki Browse this author |
| Saito, Michiyuki Browse this author →KAKEN DB |
| Kase, Satoru Browse this author →KAKEN DB |
| Noda, Kousuke Browse this author →KAKEN DB |
| Ishida, Susumu Browse this author →KAKEN DB |
| Keywords: | Central macular thickness |
| Ellipsoid zone |
| Foveal retinal pigment epithelium depigmentation |
| Japanese patients |
| Macular telangiectasia type 2 |
| Issue Date: | May-2021 |
| Publisher: | Springer |
| Journal Title: | Graefes Archive For Clinical and Experimental Ophthalmology |
| Volume: | 259 |
| Start Page: | 1179 |
| End Page: | 1189 |
| Publisher DOI: | 10.1007/s00417-020-04989-x |
| Abstract: | Purpose This study aimed to demonstrate the clinical course of Japanese patients with macular telangiectasia type 2 (MacTel-2). Methods This retrospective observational case series included 16 eyes of 8 Japanese patients (3 men and 5 women) with MacTel-2. The mean age and follow-up duration was 66.9 years and 42.8 months, respectively. Differences in best-corrected visual acuity (BCVA), funduscopic macular findings, central macular thickness (CMT), and the length of macular ellipsoid zone (EZ) loss were compared between the initial/baseline and final visits. Optical coherence tomographic changes in CMT by >= 20% and in EZ loss by >= 20% or >= 100 mu m were defined as improved or worsened. Results Numerical changes in BCVA and EZ loss during follow-up were not statistically significant. However, the mean CMT at baseline, which was lower than that of healthy control eyes (P < 0.001), significantly increased during follow-up (P = 0.041). A certain proportion of eyes showed improvement in several parameters: funduscopic findings (both parafoveal retinal graying and foveal retinal pigment epithelium depigmentation) in 29% of eyes, CMT in 21% of eyes, and EZ loss in 43% of eyes. Conclusions The non-negligible proportion of eyes with improved parameters, marked especially by macular EZ loss, suggests that Japanese patients with MacTel-2 have milder clinical features than Caucasian patients reported in the literature. |
| Rights: | This is a post-peer-review, pre-copyedit version of an article published in Graefe's Archive for Clinical and Experimental Ophthalmology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00417-020-04989-x |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/85247 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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