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Morphological features of macular telangiectasia type 2 in Japanese patients

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Title: Morphological features of macular telangiectasia type 2 in Japanese patients
Authors: Shinkai, Akihiro Browse this author
Saito, Wataru Browse this author →KAKEN DB
Hashimoto, Yuki Browse this author
Saito, Michiyuki Browse this author →KAKEN DB
Kase, Satoru Browse this author →KAKEN DB
Noda, Kousuke Browse this author →KAKEN DB
Ishida, Susumu Browse this author →KAKEN DB
Keywords: Central macular thickness
Ellipsoid zone
Foveal retinal pigment epithelium depigmentation
Japanese patients
Macular telangiectasia type 2
Issue Date: May-2021
Publisher: Springer
Journal Title: Graefes Archive For Clinical and Experimental Ophthalmology
Volume: 259
Start Page: 1179
End Page: 1189
Publisher DOI: 10.1007/s00417-020-04989-x
Abstract: Purpose This study aimed to demonstrate the clinical course of Japanese patients with macular telangiectasia type 2 (MacTel-2). Methods This retrospective observational case series included 16 eyes of 8 Japanese patients (3 men and 5 women) with MacTel-2. The mean age and follow-up duration was 66.9 years and 42.8 months, respectively. Differences in best-corrected visual acuity (BCVA), funduscopic macular findings, central macular thickness (CMT), and the length of macular ellipsoid zone (EZ) loss were compared between the initial/baseline and final visits. Optical coherence tomographic changes in CMT by >= 20% and in EZ loss by >= 20% or >= 100 mu m were defined as improved or worsened. Results Numerical changes in BCVA and EZ loss during follow-up were not statistically significant. However, the mean CMT at baseline, which was lower than that of healthy control eyes (P < 0.001), significantly increased during follow-up (P = 0.041). A certain proportion of eyes showed improvement in several parameters: funduscopic findings (both parafoveal retinal graying and foveal retinal pigment epithelium depigmentation) in 29% of eyes, CMT in 21% of eyes, and EZ loss in 43% of eyes. Conclusions The non-negligible proportion of eyes with improved parameters, marked especially by macular EZ loss, suggests that Japanese patients with MacTel-2 have milder clinical features than Caucasian patients reported in the literature.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Graefe's Archive for Clinical and Experimental Ophthalmology. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 齋藤 航

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