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Feasibility of limited resection for peripheral small-sized non-small cell lung cancer : a retrospective single-center-based study

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Title: Feasibility of limited resection for peripheral small-sized non-small cell lung cancer : a retrospective single-center-based study
Authors: Aragaki, Masato Browse this author →KAKEN DB
Hida, Yasuhiro Browse this author →KAKEN DB
Kato, Tatsuya Browse this author
Fujiwara-Kuroda, Aki Browse this author
Kaga, Kichizo Browse this author →KAKEN DB
Wakasa, Satoru Browse this author →KAKEN DB
Keywords: Non-small cell lung cancer
Limited resection
Issue Date: May-2021
Publisher: Springer
Journal Title: Journal of cancer research and clinical oncology
Volume: 147
Start Page: 1519
End Page: 1527
Publisher DOI: 10.1007/s00432-020-03441-1
Abstract: Purpose This study aimed to establish new criteria for limited resection of non-small cell lung cancer (NSCLC) based on computed tomography findings and maximum standardized uptake value (SUVmax). Methods Between December 2007 and December 2015, 611 patients underwent lung cancer surgery; of these, 70 with cT1aN0M0 who underwent limited resection were enrolled. Criteria for undergoing intentional limited resection (ILR) were (1) tumor ground-glass opacity (GGO) ratio of >= 0.75 and (2) tumor SUVmax <= 1.5. Patients who met criteria (1) and (2) underwent partial resection, and those who only met criteria (2) underwent segmentectomy as ILR. The control group was subjected to limited surgery without meeting the criteria. Results Overall, 45 and 25 patients who met the criteria were included in the ILR and control groups, respectively. In the ILR group, 13 patients underwent partial resection, and 32 underwent segmentectomy; in the control group, 18 patients underwent partial resection and 7 underwent segmentectomy. According to our criteria, no relapsed cases occurred in the ILR group, although six patients showed recurrence of lung cancer in the control group. The 5-year overall survival (OS) rates in the ILR and control groups were 100% and 67.7%, respectively, and the relapse-free survival (RFS) rates were 100% and 61.6%, respectively. The log-rank test showed that this difference was statistically significant (OS: P < 0.0001, RFS: P < 0.0001). Conclusions SUVmax may serve as a predictive marker of recurrence to determine the treatment strategy for patients with NSCLC. Patients with low GGO ratio and low SUVmax may be cured by limited resection.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Journal of Cancer Research and Clinical Oncology. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 新垣 雅人

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