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Crystal structure of A-type ATP synthase catalytic nucleotide-binding subunit A from Pyrococcus horikoshii reveals a novel domain related in the

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タイトル: Crystal structure of A-type ATP synthase catalytic nucleotide-binding subunit A from Pyrococcus horikoshii reveals a novel domain related in the
著者: Maegawa, Yuki 著作を一覧する
Morita, Hazuki 著作を一覧する
Iyaguchi, Daisuke 著作を一覧する
Yao, Min 著作を一覧する
Watanabe, Nobuhisa 著作を一覧する
Tanaka, Isao 著作を一覧する
キーワード: H+-transporting ATP synthase
A-ATPase
catalytic nucleotide-binding subunit A
archaea
X-ray crystallography
発行日: 2006年 5月
出版者: International Union of Crystallography
誌名: Acta Crystallographica Section D
巻: 62
号: 5
開始ページ: 483
終了ページ: 488
出版社 DOI: 10.1107/S0907444906006329
抄録: H+-transporting ATP synthase is a multi-subunit enzyme involved in the production of ATP, which is essential molecule for living organisms as a source of energy. Archaeal A-type ATPase (A-ATPase) is thought to act as a functional ATP synthase in Archaea and is thought to have chimeric properties of F-ATPase and V-ATPase. From the previous structural studies of F-ATPase, it is indicated that the major nucleotide-binding subunits α and β consist of three domains. The catalytic nucleotide-binding subunit A of V/A-ATPase contains an insertion of about 90 residues, which is absent from the F1-β subunit. Here we describe the first X-ray structure of the catalytic nucleotide-binding subunit A of the A1-ATPase determined at 2.55 Å resolution. A1-ATPase subunit A from Pyrococcus horikoshii consists of four domains. A novel domain, including a part of this insertion, corresponds to the “knob-like structure” observed in electron microscopy of A1-ATPase. Based on the structure, it is highly likely that this inserted domain is related to the peripheral stalk common to the A- and V-ATPases. The arrangement of this inserted domain suggests that this region plays an important role in A-ATPase as well as in V-ATPase.
Rights: Copyright © International Union of Crystallography
Relation (URI): http://scripts.iucr.org/cgi-bin/paper?mh5001
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/8534
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 渡邉 信久

 

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