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In vivo local transcranial static magnetic field stimulation alters motor behavior in normal rats
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| Title: | In vivo local transcranial static magnetic field stimulation alters motor behavior in normal rats |
| Authors: | Takamatsu, Yasuyuki Browse this author →KAKEN DB | | Inoue, Takahiro Browse this author | | Okamura, Misato Browse this author | | Ikegami, Ryo Browse this author | | Maejima, Hiroshi Browse this author →KAKEN DB |
| Keywords: | Static magnetic fields | | Neuromodulation | | Cortex | | Behavior | | Inhibition |
| Issue Date: | 14-May-2021 |
| Publisher: | Elsevier |
| Journal Title: | Neuroscience letters |
| Volume: | 753 |
| Start Page: | 135864 |
| Publisher DOI: | 10.1016/j.neulet.2021.135864 |
| Abstract: | Transcranial static magnetic field stimulation (tSMS) has inhibitory neuromodulatory effects on the human brain. Most of the studies on static magnetic fields have been performed in vitro. To further understand the biological mechanisms of tSMS, we investigated the effects of in vivo tSMS on motor behavior in normal awake rats. The skull of a male Wistar rat was exposed and a polyethylene tube was attached to the skull using dental cement at the center of the motor cortex (n = 7) or the other cortex (n = 6). By attaching a cylindrical NdFeB neodymium magnet into the tube, in vivo tSMS (REAL) was performed. For SHAM, we applied a similar size non-magnetic stainless-steel cylinder. All rats received twice each SHAM and REAL stimulation crossover design, and motor function was measured during the stimulation. Activity level and asymmetry of forelimb use were not affected, but less accurate movements in the horizontal ladder test were found in REAL stimulation of the motor cortex. This study shows that in vivo tSMS has inhibitory neuromodulatory effects on motor behavior depending on the stimulated region on the rat cortex. |
| Rights: | © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/85349 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 高松 泰行
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