Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Zinc directly stimulates cholecystokinin secretion from enteroendocrine cells and reduces gastric emptying in rats
This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Title: | Zinc directly stimulates cholecystokinin secretion from enteroendocrine cells and reduces gastric emptying in rats |
Authors: | Nakajima, Shingo Browse this author | Hira, Tohru Browse this author →KAKEN DB | Iwaya, Hitoshi Browse this author | Hara, Hiroshi Browse this author →KAKEN DB |
Keywords: | Cholecystokinin | Zinc | Gastric emptying | Transient receptor potential ankyrin 1 (TRPA1) |
Issue Date: | 15-Jul-2016 |
Journal Title: | Molecular and Cellular Endocrinology |
Volume: | 430 |
Start Page: | 108 |
End Page: | 114 |
Publisher DOI: | 10.1016/j.mce.2016.04.010 |
Abstract: | Zinc, an essential mineral element, regulates various physiological functions such as immune responses and hormone secretion. Cholecystokinin (CCK), a gut hormone, has a role in protective immunity through the regulation of gastrointestinal motility, appetite, and inflammatory response. Here, we examined the effect of zinc on CCK secretion in STC-1 cells, an enteroendocrine cell line derived from murine duodenum, and in rats. Extracellular zinc triggered CCK secretion accompanied with increased intracellular Ca2+ and Zn2+ mobilization in STC-1 cells. Zinc-induced CCK secretion was abolished in the absence of intracellular Zn2+ or extracellular calcium. Upon inhibition of transient receptor potential ankyrin 1 (TRPA1), extracellular zinc failed to increase intracellular Ca2+ and subsequent CCK secretion. In rats, oral zinc administration decreased gastric emptying through the activation of CCK signaling. These results suggest that zinc is a novel stimulant for CCK secretion through the activation of TRPA1 related to intracellular Zn2+ and Ca2+ mobilization. |
Rights: | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/85384 |
Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 比良 徹
|