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Zinc directly stimulates cholecystokinin secretion from enteroendocrine cells and reduces gastric emptying in rats

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Title: Zinc directly stimulates cholecystokinin secretion from enteroendocrine cells and reduces gastric emptying in rats
Authors: Nakajima, Shingo Browse this author
Hira, Tohru Browse this author →KAKEN DB
Iwaya, Hitoshi Browse this author
Hara, Hiroshi Browse this author →KAKEN DB
Keywords: Cholecystokinin
Gastric emptying
Transient receptor potential ankyrin 1 (TRPA1)
Issue Date: 15-Jul-2016
Journal Title: Molecular and Cellular Endocrinology
Volume: 430
Start Page: 108
End Page: 114
Publisher DOI: 10.1016/j.mce.2016.04.010
Abstract: Zinc, an essential mineral element, regulates various physiological functions such as immune responses and hormone secretion. Cholecystokinin (CCK), a gut hormone, has a role in protective immunity through the regulation of gastrointestinal motility, appetite, and inflammatory response. Here, we examined the effect of zinc on CCK secretion in STC-1 cells, an enteroendocrine cell line derived from murine duodenum, and in rats. Extracellular zinc triggered CCK secretion accompanied with increased intracellular Ca2+ and Zn2+ mobilization in STC-1 cells. Zinc-induced CCK secretion was abolished in the absence of intracellular Zn2+ or extracellular calcium. Upon inhibition of transient receptor potential ankyrin 1 (TRPA1), extracellular zinc failed to increase intracellular Ca2+ and subsequent CCK secretion. In rats, oral zinc administration decreased gastric emptying through the activation of CCK signaling. These results suggest that zinc is a novel stimulant for CCK secretion through the activation of TRPA1 related to intracellular Zn2+ and Ca2+ mobilization.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 比良 徹

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