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GLP-1 Secretion in Response to Oral and Luminal Palatinose (Isomaltulose) in Rats

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Title: GLP-1 Secretion in Response to Oral and Luminal Palatinose (Isomaltulose) in Rats
Authors: HIRA, Tohru Browse this author →KAKEN DB
MURAMATSU, Maya Browse this author
OKUNO, Masahiro Browse this author
HARA, Hiroshi Browse this author →KAKEN DB
Keywords: palatinose
isomaltulose
GLP-1
enteroendocrine cells
Issue Date: 2011
Journal Title: Journal of Nutritional Science and Vitaminology
Volume: 57
Issue: 1
Start Page: 30
End Page: 35
Publisher DOI: 10.3177/jnsv.57.30
Abstract: Palatinose (isomaltulose), a slowly digested disaccharide, is used as a non-cariogenic sugar and as a sucrose substitute in several foods. Because of its ability to lower postprandial glycemia, palatinose may be beneficial as a treatment for impaired glucose metabolism. Glucagon-like peptide-1 (GLP-1) improves glycemia via enhancing pancreatic beta-cell functions. The secretion of GLP-1 is stimulated by sugars, including glucose and artificial sweeteners. In this study, we examined whether palatinose induced GLP-1 secretion in vivo and in vitro. Firstly, portal GLP-1 and glucose were measured after oral administration of palatinose or sucrose in conscious rats. Secondly, portal GLP-1 and glucose were measured after jejunal or ileal administration of each sugar in anesthetized rats. Finally, GLUTag, a murine GLP-1-producing cell line, was exposed to several sugars, including palatinose and sucrose, to observe the direct effect of these sugars on GLP-1 secretion. Compared with sucrose, palatinose enhanced portal GLP-1 level when administered orally in conscious rats. Both palatinose and sucrose induced a significant increase in portal GLP-1 after jejunal or ileal administration of each sugar in anesthetized rats. Ileal administration triggered a greater response than did jejunal administration. Glycemic responses were higher in sucrose-treated rats than in palatinose-treated rats in every experiment. In GLUTag cells, glucose induced a significant increase in GLP-1 secretion, but neither sucrose nor palatinose had an effect. These data demonstrate that luminal palatinose induces GLP-1 secretion in rats. However, it is likely that GLP-1 secretion is triggered mainly by glucose released in the lumen rather than by palatinose itself.
Type: article (author version)
URI: http://hdl.handle.net/2115/85397
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 比良 徹

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