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A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/8543

Title: A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice
Authors: Lee, Byoung-Hee Browse this author
Yoshimatsu, Kumiko Browse this author
Araki, Koichi Browse this author
Okumura, Megumi Browse this author
Nakamura, Ichiro Browse this author →KAKEN DB
Arikawa, Jiro Browse this author →KAKEN DB
Keywords: Envelope
Hantavirus
Pseudotype
Issue Date: 5-Apr-2006
Publisher: Elsevier
Journal Title: Vaccine
Volume: 24
Issue: 15
Start Page: 2928
End Page: 2934
Publisher DOI: 10.1016/j.vaccine.2005.12.040
PMID: 16426712
Abstract: We examined whether a vesicular stomatitis virus (VSV) pseudotype bearing the hantavirus envelope glycoproteins (GPs) G1 and G2 (VSVÎ G*HTN) could be used as a safe and effective alternative to native hantavirus. Mice were immunized with purified particles of VSVÎ G*HTN. After the second immunization, all mice produced anti-GP antibody as detected in ELISA and a neutralization test. After the third immunization, the mice were challenged with Hantaan virus. Neither anti-NP antibody production nor Hantaan virus-specific CD8 T-cell reactions were detected in these mice. The present study demonstrated the potential of using a pseudotype VSV system as a tool for developing a hantavirus vaccine.
Relation: http://www.sciencedirect.com/science/journal/0264410X
Type: article (author version)
URI: http://hdl.handle.net/2115/8543
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 有川二郎

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