A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice

Lee, Byoung-Hee; Yoshimatsu, Kumiko; Araki, Koichi; Okumura, Megumi; Nakamura, Ichiro; Arikawa, Jiro

doi:10.1016/j.vaccine.2005.12.040


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A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice

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Title:	A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice
Authors:	Lee, Byoung-Hee Browse this author
	Yoshimatsu, Kumiko Browse this author
	Araki, Koichi Browse this author
	Okumura, Megumi Browse this author
	Nakamura, Ichiro Browse this author →KAKEN DB
	Arikawa, Jiro Browse this author →KAKEN DB
Keywords:	Envelope
	Hantavirus
	Pseudotype
Issue Date:	5-Apr-2006
Publisher:	Elsevier
Journal Title:	Vaccine
Volume:	24
Issue:	15
Start Page:	2928
End Page:	2934
Publisher DOI:	10.1016/j.vaccine.2005.12.040
PMID:	16426712
Abstract:	We examined whether a vesicular stomatitis virus (VSV) pseudotype bearing the hantavirus envelope glycoproteins (GPs) G1 and G2 (VSVÎ GHTN) could be used as a safe and effective alternative to native hantavirus. Mice were immunized with purified particles of VSVÎ GHTN. After the second immunization, all mice produced anti-GP antibody as detected in ELISA and a neutralization test. After the third immunization, the mice were challenged with Hantaan virus. Neither anti-NP antibody production nor Hantaan virus-specific CD8 T-cell reactions were detected in these mice. The present study demonstrated the potential of using a pseudotype VSV system as a tool for developing a hantavirus vaccine.
Relation:	http://www.sciencedirect.com/science/journal/0264410X
Type:	article (author version)
URI:	http://hdl.handle.net/2115/8543
Appears in Collections:	医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 有川二郎

OAI-PMH ( junii2 , jpcoar_1.0 )

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