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Biological modification of tooth surface by laser-based apatite coating techniques

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Title: Biological modification of tooth surface by laser-based apatite coating techniques
Authors: Miyaji, Hirofumi Browse this author →KAKEN DB
Oyane, Ayako Browse this author →KAKEN DB
Narazaki, Aiko Browse this author →KAKEN DB
Keywords: Apatite
Calcium phosphate
Laser-induced forward transfer
Tooth root
Issue Date: 26-Mar-2022
Publisher: Elsevier
Journal Title: Journal of Oral Biosciences
Volume: 64
Issue: 2
Start Page: 217
End Page: 221
Publisher DOI: 10.1016/j.job.2022.03.004
PMID: 35351642
Abstract: Background: Development of new clinical regenerative procedures is needed for the reconstruction of the connective tissue attachment lost to periodontal disease. Apatite coating on the affected root surfaces could improve root surface biocompatibility and promote the reestablishment of connective tissue attachment. Highlight: We developed two novel techniques that use laser light for coating the tooth surface with apatite. In the laser-assisted biomimetic (LAB) process, a tooth substrate was placed in a supersaturated calcium phosphate solution and irradiated for 30 min with low-energy pulsed laser light. Due to the laser-assisted pseudo-biomineralization, a submicron-thick apatite film was created on the laser-irradiated tooth surface. Furthermore, we created a fluoride-incorporated apatite film on the tooth surface using the LAB process and demonstrated its antibacterial activity against Streptococcus mutans. In the laser-induced forward transfer with optical stamp (LIFTOP) process, a thin apatite film loaded with the cell-adhesion protein, fibronectin, was prepared beforehand as a raw material on the optical stamp (carbon- and polydimethylsiloxane-coated support) by a conventional biomimetic process. After irradiation with a single laser pulse, the film (microchip) was transferred onto a tooth substrate via laser ablation of the carbon sacrificial layer. The LIFTOP process requires only a short processing time and has a minimal heat effect on the film; thus, the film exhibits cell adhesion activity even after the LIFTOP process. Conclusion: The LAB and LIFTOP processes have the potential as novel tools for tooth surface modification in the treatment of periodontal disease.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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