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Ultrasonic irrigation of periodontal pocket with surface pre-reacted glass-ionomer (S-PRG) nanofiller dispersion improves periodontal parameters in beagle dogs

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Title: Ultrasonic irrigation of periodontal pocket with surface pre-reacted glass-ionomer (S-PRG) nanofiller dispersion improves periodontal parameters in beagle dogs
Authors: Miyaji, Hirofumi Browse this author →KAKEN DB
Mayumi, Kayoko Browse this author
Kanemoto, Yukimi Browse this author
Okamoto, Ichie Browse this author
Hamamoto, Asako Browse this author
Kato, Akihito Browse this author →KAKEN DB
Sugaya, Tsutomu Browse this author →KAKEN DB
Akasaka, Tsukasa Browse this author →KAKEN DB
Tanaka, Saori Browse this author →KAKEN DB
Keywords: 16S rRNA next-generation sequencer
Actinomyces naeslundii
Antibacterial effect
Surface pre-reacted glass-ionomer (S-PRG) nanofiller
Ultrasonic scaler system
Issue Date: 4-Mar-2022
Publisher: Elsevier
Journal Title: Journal of Oral Biosciences
Volume: 64
Issue: 2
Start Page: 222
End Page: 228
Publisher DOI: 10.1016/j.job.2022.02.006
PMID: 35257846
Abstract: Objectives: Surface pre-reacted glass-ionomer (S-PRG) nanofiller, an antibacterial ion-releasing bioactive glass, has been shown to adhere to tooth surfaces and reported to improve inflammatory parameters in experimental periodontitis. In this study, cementum substrate was irrigated ultrasonically with dispersion to examine in-vitro nanofiller adhesion and antibacterial activity. Moreover, periodontal pockets in a beagle dog were ultrasonically irrigated with dispersion to assess periodontal healing. Methods: The morphology of human cementum irrigated with S-PRG nanofiller dispersion was examined by scanning electron microscopy and energy dispersive X-ray spectrometry. The antibacterial activity of the treated cementum was tested using Actinomyces naeslundii. In addition, experimentally formed periodontal pockets in beagle dog were ultrasonically irrigated with S-PRG nanofiller dispersion. Periodontal parameters (gingival index, bleeding on probing, probing pocket depth, and clinical attachment level) were measured from baseline (0 weeks) through 12 weeks. Moreover, the effects of irrigation with S-PRG nanofiller on changes in periodontal microflora and bone healing were analyzed. Results: After ultrasonic irrigation, S-PRG nanofiller adhered to the cementum and exhibited antibacterial activity. The periodontal parameters were shown to improve following ultrasonic irrigation with S-PRG nanofiller dispersion. Analysis by next-generation sequencing revealed that the ratio of red-complex species decreased in the pockets irrigated with S-PRG nanofiller dispersion. In addition, the S-PRG nanofiller showed the potential to promote bone healing. Conclusions: Ultrasonic irrigation with S-PRG nanofiller dispersion using an ultrasonic scaler system permitted delivery of the S-PRG nanofiller to the root surface, providing improved parameters in experimental periodontitis and modifying the composition of subgingival periodontal microflora.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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