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Diagnostic Accuracy of Cell Block Preparations and Clinical Features Affecting It in Vitreoretinal Lymphoma

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Title: Diagnostic Accuracy of Cell Block Preparations and Clinical Features Affecting It in Vitreoretinal Lymphoma
Authors: Kase, Satoru Browse this author →KAKEN DB
Namba, Kenichi Browse this author →KAKEN DB
Iwata, Daiju Browse this author →KAKEN DB
Mizuuchi, Kazuomi Browse this author →KAKEN DB
Suzuki, Kayo Browse this author
Ito, Takako Browse this author
Hase, Keitaro Browse this author
Kitaichi, Nobuyoshi Browse this author
Ishida, Susumu Browse this author →KAKEN DB
Keywords: vitreoretinal lymphoma
cell block preparations
subretinal infiltrates
optical coherence tomography
Issue Date: Mar-2022
Publisher: MDPI
Journal Title: Journal of clinical medicine
Volume: 11
Issue: 5
Start Page: 1391
Publisher DOI: 10.3390/jcm11051391
Abstract: Purpose: The purpose of this study was to examine the diagnostic accuracy of the cell block (CB) method and clinical features affecting it in patients with vitreoretinal lymphoma (VRL). Methods: This study enrolled 38 eyes in 33 VRL patients, and 7 eyes in 7 patients with idiopathic uveitis who underwent diagnostic vitrectomy. Medical records including the results of CB cytology, interleukin (IL)-10/-6 concentrations, and immunoglobulin heavy chain gene (IgH) rearrangement were retrospectively searched. Results: Patients with VRL comprised 16 women and 17 men, and the age of onset ranged from 44 to 85 years (mean: 70 years). CB preparations detected large malignant cells in 35 eyes (92%), whereas the other 3 VRL eyes were negative. Two of the latter three eyes showed subretinal infiltrates, which existed in 7 of 35 CB-positive eyes. Intravitreal IL-10 and -6 concentrations were 1866 +/- 4088 pg/mL and 98 +/- 139 pg/mL, respectively, and the rate of IL-10/-6 >1 was 86.9%. The presence of IgH monoclonality was 63.2%. In patients with uveitis, CB specimens revealed no atypical but small inflammatory cells. IL-6 concentration was 311.1 +/- 240 pg/mL, whereas IL-10 was undetectable in six eyes, and the IL-negative rate was 85.7%. Six eyes (85.7%) with uveitis showed no IgH monoclonality. Conclusions: Diagnostic accuracy of CB preparations in VRL could achieve an equivalent outcome to IL ratio calculation and IgH monoclonality detection. The appearance of subretinal infiltrates may diminish the CB positivity.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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