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Diagnostic Accuracy of Cell Block Preparations and Clinical Features Affecting It in Vitreoretinal Lymphoma
| Title: | Diagnostic Accuracy of Cell Block Preparations and Clinical Features Affecting It in Vitreoretinal Lymphoma |
| Authors: | Kase, Satoru Browse this author →KAKEN DB | | Namba, Kenichi Browse this author →KAKEN DB | | Iwata, Daiju Browse this author →KAKEN DB | | Mizuuchi, Kazuomi Browse this author →KAKEN DB | | Suzuki, Kayo Browse this author | | Ito, Takako Browse this author | | Hase, Keitaro Browse this author | | Kitaichi, Nobuyoshi Browse this author | | Ishida, Susumu Browse this author →KAKEN DB |
| Keywords: | vitreoretinal lymphoma | | cell block preparations | | subretinal infiltrates | | optical coherence tomography |
| Issue Date: | Mar-2022 |
| Publisher: | MDPI |
| Journal Title: | Journal of clinical medicine |
| Volume: | 11 |
| Issue: | 5 |
| Start Page: | 1391 |
| Publisher DOI: | 10.3390/jcm11051391 |
| Abstract: | Purpose: The purpose of this study was to examine the diagnostic accuracy of the cell block (CB) method and clinical features affecting it in patients with vitreoretinal lymphoma (VRL). Methods: This study enrolled 38 eyes in 33 VRL patients, and 7 eyes in 7 patients with idiopathic uveitis who underwent diagnostic vitrectomy. Medical records including the results of CB cytology, interleukin (IL)-10/-6 concentrations, and immunoglobulin heavy chain gene (IgH) rearrangement were retrospectively searched. Results: Patients with VRL comprised 16 women and 17 men, and the age of onset ranged from 44 to 85 years (mean: 70 years). CB preparations detected large malignant cells in 35 eyes (92%), whereas the other 3 VRL eyes were negative. Two of the latter three eyes showed subretinal infiltrates, which existed in 7 of 35 CB-positive eyes. Intravitreal IL-10 and -6 concentrations were 1866 +/- 4088 pg/mL and 98 +/- 139 pg/mL, respectively, and the rate of IL-10/-6 >1 was 86.9%. The presence of IgH monoclonality was 63.2%. In patients with uveitis, CB specimens revealed no atypical but small inflammatory cells. IL-6 concentration was 311.1 +/- 240 pg/mL, whereas IL-10 was undetectable in six eyes, and the IL-negative rate was 85.7%. Six eyes (85.7%) with uveitis showed no IgH monoclonality. Conclusions: Diagnostic accuracy of CB preparations in VRL could achieve an equivalent outcome to IL ratio calculation and IgH monoclonality detection. The appearance of subretinal infiltrates may diminish the CB positivity. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/85490 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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