| Title: | Prediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis C virus eradication |
| Authors: | Nakai, Masato Browse this author |
| Yamamoto, Yoshiya Browse this author |
| Baba, Masaru Browse this author |
| Suda, Goki Browse this author →KAKEN DB |
| Kubo, Akinori Browse this author |
| Tokuchi, Yoshimasa Browse this author |
| Kitagataya, Takashi Browse this author |
| Yamada, Ren Browse this author |
| Shigesawa, Taku Browse this author |
| Suzuki, Kazuharu Browse this author |
| Nakamura, Akihisa Browse this author |
| Sho, Takuya Browse this author |
| Morikawa, Kenichi Browse this author |
| Ogawa, Koji Browse this author →KAKEN DB |
| Furuya, Ken Browse this author |
| Sakamoto, Naoya Browse this author →KAKEN DB |
| Issue Date: | 27-Jan-2022 |
| Publisher: | Nature Portfolio |
| Journal Title: | Scientific reports |
| Volume: | 12 |
| Issue: | 1 |
| Start Page: | 1449 |
| Publisher DOI: | 10.1038/s41598-022-05492-5 |
| Abstract: | Liver stiffness measurement (LSM) is a useful tool for assessing advanced liver fibrosis, an important risk factor for hepatocellular carcinoma (HCC) following hepatitis C (HCV) eradication. This study aimed to clarify the non-invasive factors associated with HCC following sustained virological response (SVR) and to identify the low-risk group. 567 patients without history of HCC who achieved SVR at 24 weeks (SVR24) after IFN-free treatment were retrospectively analyzed. The cumulative incidence of HCC and the risk factors were examined using pre-treatment and SVR24 data. The median observation period was 50.2 months. Thirty cases of HCC were observed, and the 4-year cumulative incidence of HCC was 5.9%. In multivariate analysis, significant pre-treatment factors were age >= 71 years (hazard ratio [HR]: 3.402) and LSM >= 9.2 kPa (HR: 6.328); SVR24 factors were age >= 71 years (HR: 2.689) and LSM >= 8.4 kPa (HR: 6.642). In cases with age < 71 years and LSM < 8.4 kPa at the time of SVR24, the 4-year cumulative incidence of HCC was as low as 1.1%. Both pre-treatment LSM (>= 9.2 kPa) and SVR24 LSM (>= 8.4 kPa) and age (>= 71 years) are useful in predicting the risk of HCC after SVR with IFN-free treatment. Identification of low-risk individuals may improve the efficiency of follow-up. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/85503 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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