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Microscopic Fractional Anisotropy Detects Cognitive Training-Induced Microstructural Brain Changes

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Title: Microscopic Fractional Anisotropy Detects Cognitive Training-Induced Microstructural Brain Changes
Authors: Li, Xinnan Browse this author
Sawamura, Daisuke Browse this author
Hamaguchi, Hiroyuki Browse this author
Urushibata, Yuta Browse this author
Feiweier, Thorsten Browse this author
Ogawa, Keita Browse this author
Tha, Khin Khin Browse this author →KAKEN DB
Keywords: double diffusion encoding
microscopic fractional anisotropy
cognitive training
Issue Date: Feb-2022
Publisher: MDPI
Journal Title: Tomography
Volume: 8
Issue: 1
Start Page: 33
End Page: 44
Publisher DOI: 10.3390/tomography8010004
Abstract: Cognitive training-induced neuroplastic brain changes have been reported. This prospective study evaluated whether microscopic fractional anisotropy (mu FA) derived from double diffusion encoding (DDE) MRI could detect brain changes following a 4 week cognitive training. Twenty-nine healthy volunteers were recruited and randomly assigned into the training (n = 21) and control (n = 8) groups. Both groups underwent brain MRI including DDE MRI and 3D-T1-weighted imaging twice at an interval of 4-6 weeks, during which the former underwent the training. The training consisted of hour-long dual N-back and attention network tasks conducted five days per week. Training and time-related changes of DDE MRI indices (mu FA, fractional anisotropy (FA), and mean diffusivity (MD)) and the gray and white matter volume were evaluated using mixed-design analysis of variance. In addition, any significant imaging indices were tested for correlation with cognitive training-induced task performance changes, using partial correlation analyses. mu FA in the left middle frontal gyrus decreased upon the training (53 voxels, uncorrected p < 0.001), which correlated moderately with response time changes in the orienting component of attention (r = -0.521, uncorrected p = 0.032). No significant training and time-related changes were observed for other imaging indices. Thus, mu FA can become a sensitive index to detect cognitive training-induced neuroplastic changes.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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