| Title: | Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant |
| Authors: | Suzuki, Rigel Browse this author |
| Yamasoba, Daichi Browse this author |
| Kimura, Izumi Browse this author |
| Wang, Lei Browse this author |
| Kishimoto, Mai Browse this author |
| Ito, Jumpei Browse this author |
| Morioka, Yuhei Browse this author |
| Nao, Naganori Browse this author |
| Nasser, Hesham Browse this author |
| Uriu, Keiya Browse this author |
| Kosugi, Yusuke Browse this author |
| Tsuda, Masumi Browse this author |
| Orba, Yasuko Browse this author |
| Sasaki, Michihito Browse this author |
| Shimizu, Ryo Browse this author |
| Kawabata, Ryoko Browse this author |
| Yoshimatsu, Kumiko Browse this author |
| Asakura, Hiroyuki Browse this author |
| Nagashima, Mami Browse this author |
| Sadamasu, Kenji Browse this author |
| Yoshimura, Kazuhisa Browse this author |
| Sawa, Hirofumi Browse this author |
| Ikeda, Terumasa Browse this author |
| Irie, Takashi Browse this author |
| Matsuno, Keita Browse this author |
| Tanaka, Shinya Browse this author →KAKEN DB |
| Fukuhara, Takasuke Browse this author →KAKEN DB |
| Sato, Kei Browse this author |
| Issue Date: | 24-Mar-2022 |
| Publisher: | Nature Portfolio |
| Journal Title: | Nature |
| Volume: | 603 |
| Issue: | 7902 |
| Start Page: | 700 |
| End Page: | 705 |
| Publisher DOI: | 10.1038/s41586-022-04462-1 |
| Abstract: | The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern(1). In this study, our statistical modelling suggests that Omicron has spread more rapidly than the Delta variant in several countries including South Africa. Cell culture experiments showed Omicron to be less fusogenic than Delta and than an ancestral strain of SARS-CoV-2.Although the spike (S) protein of Delta is efficiently cleaved into two subunits, which facilitates cell-cell fusion(2,3), the Omicron S protein was less efficiently cleaved compared to the S proteins of Delta and ancestral SARS-CoV-2. Furthermore, in a hamster model, Omicron showed decreased lung infectivity and was less pathogenic compared to Delta and ancestral SARS-CoV-2. Our multiscale investigations reveal the virological characteristics of Omicron, including rapid growth in the human population, lower fusogenicity and attenuated pathogenicity. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/85527 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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