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Hemoglobin Concentration during Early Pregnancy as an Accurate Predictor of Anemia during Late Pregnancy

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Title: Hemoglobin Concentration during Early Pregnancy as an Accurate Predictor of Anemia during Late Pregnancy
Authors: Noshiro, Kiwamu Browse this author
Umazume, Takeshi Browse this author →KAKEN DB
Hattori, Rifumi Browse this author
Kataoka, Soromon Browse this author →KAKEN DB
Yamada, Takashi Browse this author →KAKEN DB
Watari, Hidemichi Browse this author →KAKEN DB
Keywords: anemia
transferrin saturation
Issue Date: Feb-2022
Publisher: MDPI
Journal Title: Nutrients
Volume: 14
Issue: 4
Start Page: 839
Publisher DOI: 10.3390/nu14040839
Abstract: It is undetermined which blood variables related to iron storage during the first trimester of pregnancy could efficiently predict anemia occurring during the third trimester. Red blood cell count (RBC), hemoglobin concentration, hematocrit, ferritin, iron, and total iron binding capacity (TIBC) were assessed longitudinally during the first, second, and third trimesters of 231 healthy Japanese women. None of the patients had anemia in the first trimester and none used iron supplementation before the second trimester blood test. Anemia was defined as hemoglobin (Hb) < 11 g/dL for the first trimester and Hb < 10.0 g/dL for the third trimester. Forty-seven (20%) women developed anemia in the third trimester. The first trimester RBC, Hb, hematocrit, and ferritin levels were significantly lower in women with third-trimester anemia than those without anemia. The first trimester hemoglobin level exhibited a greater area under the curve of the receiver operating characteristic curve for prediction of the third trimester anemia than other blood variables; the optimal cut-off (12.6 g/dL) of hemoglobin yielded a sensitivity of 83% (39/47). First trimester hemoglobin levels were significantly better predictors of anemia during the third trimester than the indices of iron storage, including serum iron, ferritin, and TIBC levels.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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