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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Aleukemic Extramedullary Blast Crisis as an Initial Presentation of Chronic Myeloid Leukemia with E1A3 BCR-ABL1 Fusion Transcript
| Title: | Aleukemic Extramedullary Blast Crisis as an Initial Presentation of Chronic Myeloid Leukemia with E1A3 BCR-ABL1 Fusion Transcript |
| Authors: | Miyashita, Naoki Browse this author | | Onozawa, Masahiro Browse this author →KAKEN DB | | Suto, Keito Browse this author | | Fujisawa, Shinichi Browse this author | | Okazaki, Nanase Browse this author | | Hidaka, Daisuke Browse this author | | Ohigashi, Hiroyuki Browse this author →KAKEN DB | | Yasumoto, Atsushi Browse this author →KAKEN DB | | Sugita, Junichi Browse this author | | Hashimoto, Daigo Browse this author →KAKEN DB | | Matsuno, Yoshihiro Browse this author →KAKEN DB | | Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | e1a3 | | extramedullary blast crisis | | Philadelphia (Ph) chromosome | | BCR-ABL1 |
| Issue Date: | 1-Apr-2022 |
| Publisher: | 日本内科学会(The Japanese Society of Internal Medicine) |
| Journal Title: | Internal medicine |
| Volume: | 61 |
| Issue: | 7 |
| Start Page: | 1049 |
| End Page: | 1054 |
| Publisher DOI: | 10.2169/internalmedicine.8319-21 |
| Abstract: | Right neck swelling and pain occurred in a 49-year-old man. A Blood count showed a slight increase in platelet count without leukemoid reaction. After a biopsy of the cervical mass and bone marrow aspiration, a diagnosis of extramedullary blast crisis (EBC) of chronic myeloid leukemia (CML) was made. Fluorescence in situ hybridization (FISH) analysis showed a BCR-ABL1 fusion signal, but results of real-time polymerase chain reaction (RT-PCR) for major and minor BCR-ABL1 transcripts were negative. We identified a rare e1a 3 BCR-ABL1 fusion transcript. Administration of dasatinib resulted in disappearance of the extramedullary tumor. This is the first reported case of CML-EBC with e1a3 transcript. An aleukemic extramedullary tumor can be the initial presentation of CML. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/85622 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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