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Alterations of choroidal circulation and vascular morphology in a patient with chronic myeloid leukemia before and after chemotherapy

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Title: Alterations of choroidal circulation and vascular morphology in a patient with chronic myeloid leukemia before and after chemotherapy
Authors: Mitamura, Mizuho Browse this author
Kase, Satoru Browse this author →KAKEN DB
Hirooka, Kiriko Browse this author
Endo, Hiroaki Browse this author
Ito, Yuki Browse this author
Cho, Yuko Browse this author
Ishida, Susumu Browse this author →KAKEN DB
Keywords: Chronic myeloid leukemia
Leukemic retinopathy
Laser speckle flowgraphy
Optical coherence tomography
Binarization method
Issue Date: 7-Apr-2022
Publisher: BioMed Central
Journal Title: BMC ophthalmology
Volume: 22
Issue: 1
Start Page: 160
Publisher DOI: 10.1186/s12886-022-02380-4
Abstract: Background Chronic myeloid leukemia (CML) is known to cause leukemic retinopathy due to leukemia cell invasion into the choroid; however, details of the circulatory dynamics and morphological changes in the choroid are unknown. The aim of this study was to present a case of leukemic retinopathy and examine choroidal circulatory and structural analyses using laser speckle flowgraphy (LSFG) and optical coherence tomography with a binarization method, respectively. Case presentation A 15-year-old male diagnosed with CML complained of blurred vision in his right eye. He was ophthalmologically diagnosed with leukemic retinopathy due to retinal hemorrhage in both eyes. Tyrosine kinase inhibitors achieved complete cytogenetic remission and resolution of retinal hemorrhages at 6 months after treatment. After the treatment, the best-corrected visual acuity had recovered from 0.1 to 1.2 oculus dexter (OD) and remained at 1.5 oculus sinister (OS). The rate of change in macular blood flow assessed by the mean blur rate on LSFG was 18.3% increase OD and 25.2% decrease OS 19 months after treatment. The central choroidal thickness showed 0.4 and 3.1% reductions OD and OS, respectively. The binarization technique demonstrated that the rate of luminal areas in choroidal areas exhibited 3.2% increase OD but 4.8% decrease OS. Conclusion Choroidal blood flow improved OD after treatment for CML, while it deteriorated OS, together with choroidal thinning due to reduction of luminal areas. The degrees of leukemia cell invasion into the choroidal tissue and tissue destruction might be different between the eyes in this case.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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