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Prostaglandin-related immune suppression in cattle

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Title: Prostaglandin-related immune suppression in cattle
Authors: Sajiki, Y. Browse this author
Konnai, S. Browse this author
Ikenaka, Y. Browse this author
Okagawa, T. Browse this author
Maekawa, N. Browse this author
Logullo, C. Browse this author
Vaz Jr, I. da Silva Browse this author
Murata, S. Browse this author
Ohashi, K. Browse this author
Keywords: Cattle
Prostaglandin A(1)
Th1 response
Issue Date: Jun-2021
Publisher: Elsevier
Journal Title: Veterinary Immunology and Immunopathology
Volume: 236
Start Page: 110238
Publisher DOI: 10.1016/j.vetimm.2021.110238
Abstract: Prostaglandins (PGs) are lipid mediators derived from arachidonic acid by several enzymes including cyclooxygenase (COX)-1 and COX-2. We have previously shown that PGE2 regulates immune responses, such as Th1 cytokine production and T-cell proliferation, in cattle. However, it is still unclear whether other PGs are involved in the regulation of immune responses in cattle. Here, immunosuppressive profiles of PGs (PGA(1), PGB(2), PGD(2), PGE(2), PGF(1 alpha) and PGF(2 alpha)) were firstly examined using bovine peripheral blood mononuclear cells (PBMCs). In addition to PGE(2), PGA(1) significantly inhibited Th1 cytokine production from PBMCs in cattle. Further analyses focusing on PGA(1) revealed that treatment with PGA(1) in the presence of concanavalin A (con A) downregulated CD69, an activation marker, and IFN-gamma expression in both CD4(+) and CD8(+) T cells. Sorted CD3(+) T cells stimulated with con A were cultivated with PGA1, and IFN-gamma and TNF-alpha concentrations decreased upon PGA(1) treatment. Taken together, these results suggest that the treatment with PGA(1) in vitro inhibits T-cell activation, especially Th1 cytokine production, in cattle.
Rights: ©2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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